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Katecholaminverhalten, Adrenorezeptorendichte an intakten Zellen und Katecholaminempfindlichkeit bei einer Patientin mit orthostatischer Hypotonie

Plasma and urinary catecholamines, adrenoreceptor density, and sensitivity to catecholamines were investigated in a patient with primary orthostatic hypotension

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Summary

We evaluated sympathetic nervous system function in a patient with primary orthostatic hypotension. Plasma catecholamine levels — ecept for dopamine levels — and urinary catecholamine excretion were decreased, alpha-adrenoreceptor responsiveness to noradrenaline and beta-adrenoreceptor responsiveness to isoproterenol were increased according to increased beta-2-adrenoreceptor density on intact polymorphonuclear leukocytes. Alpha-2-adrenoreceptor density on intact platelets and adrenaline-induced platelet aggregation in vitro, however, were unchanged. We evolved a therapeutic regimen with fludrocortisone, propranolol, and dihydroergotamine that allowed the patient to resume nearly a regular degree of mobility.

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Abbreviations

A:

Adrenalin

ACTH:

Adreno-corticotropes Hormon

B max :

maximale Bindung des Radioliganden, berechnet mittels „Scatchard-Analyse“

DA:

Dopamin

FSH:

Follikel stimulierendes Hormon

g/f:

gebundene zur freien Konzentration des Radioliganden

3H-DHA:

3H-Dihydroalprenolol

HF:

Herzfrequenz

K D :

Dissoziationskonstante

LH:

Luteotropes Hormon

NA:

Noradrenalin

RR:

arterieller Blutdruck

STH:

Somatotropes Hormon

TSH:

Thyreoidea stimulierendes Hormon

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Lehmann, M., Gastmann, U., Tauber, R. et al. Katecholaminverhalten, Adrenorezeptorendichte an intakten Zellen und Katecholaminempfindlichkeit bei einer Patientin mit orthostatischer Hypotonie. Klin Wochenschr 64, 1249–1254 (1986). https://doi.org/10.1007/BF01734468

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Key words

  • Primary orthostatic hypotension
  • Sympathetic system
  • Adrenoreceptors