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Environmental Geochemistry and Health

, Volume 12, Issue 1–2, pp 15–16 | Cite as

Microanalysis of Alzheimer disease NFT and plaques

  • R. C. Moretz
  • K. Iqbal
  • H. M. Wisniewski
Article

Abstract

Electron probe energy dispersive microanalysis of isolated andin situ neurofibrillary tangles (NFT) and neuritic (senile) plaque cores have been done to investigate the levels of Al, Si, Ca and Fe in the leading lesions of Alzheimer disease neuropathology. Varying levels of Si and Al, and to a lesser extent Ca, have been co-localized in about one half of the NFT and plaques examined using X-ray mapping. The variability of detection and the low levels of Al present indicates that aluminum is not required for the formation of the NFT and that aluminosilicates are not involved in the formation of the plaque core.

Keywords

Aluminum Geochemistry Alzheimer Disease Vary Level Electron Probe 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Sciences and Technology Letters 1990

Authors and Affiliations

  • R. C. Moretz
    • 1
  • K. Iqbal
    • 1
  • H. M. Wisniewski
    • 1
  1. 1.Institute for Basic Research in Developmental Disabilities, Departments of Pathological Neurobiology and Pathological BiochemistryNew York State Office of Mental Retardation and Developmental DisabilitiesStaten IslandUSA

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