Blut

, Volume 61, Issue 5, pp 314–316

Post-transfusion malaria in thalassaemia patients

  • N. J. Choudhury
  • M. L. Dubey
  • J. G. Jolly
  • Anju Kalra
  • R. C. Mahajan
  • N. K. Ganguly
Original article

Summary

A total of 125 β-thalassaemia patients receiving repeated blood transfusions were screened by Giemsa stain, Acridine-orange stain and antigen detection for evidence of malaria infection on each visit. A total of 8 (6.4%) of the patients developed post-transfusion malaria (PMT) as confirmed by tracing the infected blood donors. A high incidence of PTM in thalassaemia patients appears to be due to the use of fresh blood and the high frequency of blood transfusions required by these patients. Antigen detection using monoclonal antibody was found to be more sensitive for diagnosis of PTM and for screening suspected donors than the conventional blood smear examination methods and is therefore recommended for routine blood donor screening to rule out malaria infection.

Key words

Transfusion malaria Thalassaemia Antigen detection 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Friedman MJ (1979) Oxidant damage mediates variant red cell resistance to malaria. Nature 280: 245–247Google Scholar
  2. 2.
    Greenberg AE, Dinh PN, Mann JN, Kabote N, Colebunders RL, Francis H, Quinn TC, Baudoux P, Lymba B, Darachi F (1988) The association between malaria, blood transfusion and HIV seropositivity in a pediatric population in Kinshasa, Zaire. JAMA 259: 545–549Google Scholar
  3. 3.
    Haldane JBS (1949) Disease and evolution. Ric Sci 19 [Suppl): 68Google Scholar
  4. 4.
    Halsted JA, Halsted CH (1981) The laboratory in clinical medicine-interpretation and application (2nd edn). WB Saunders, Philadelphia, pp 898–899Google Scholar
  5. 5.
    Ifediba TC, Stern A, Ibrahim A, Rieder RF (1985)Plasmodium falciparum in vitro: Diminished growth in haemoglobin H disease erythrocytes. Blood 65: 452–455Google Scholar
  6. 6.
    Kaminsky R, Kruger N, Hempelmann E, Bommer W (1987) Reduced development ofP. falciparum in β-thalassaemia erythrocytes. Trop Dis Bull 84: 576–577Google Scholar
  7. 7.
    Livingstone FB (1971) Malaria and human polymorphism. Ann Rev Genet 5: 33–64Google Scholar
  8. 8.
    Lupascu G, Bossie Agavriloraei A, Bona C, Ioanid L, Smolinski M (1967) Valeur de la reaction d' immunofluorescence dans le depistage des parasitemies asymptomatiques a plasmodium malariae. Bull WHO 36: 485–490Google Scholar
  9. 9.
    Luzzatto L (1979) Genetics of red cell and susceptibility to malaria. Blood 54: 961–976Google Scholar
  10. 10.
    Shute GT, Sodeman TM (1973) Identification of malaria parasite by fluorescence microscopy and acridine orange staining. Bull WHO 48: 591–596Google Scholar
  11. 11.
    Trager W, Jensen JB (1976) Human malaria parasite in continous culture. Science 193: 673–675Google Scholar
  12. 12.
    Widmann FK (1985) Technical manual (9th edn) American Association of Blood Banks, Arlington, USAGoogle Scholar
  13. 13.
    Willcox M, Bjorkman A, Brohult J (1983) A case control study in northern Liberia ofP. falciparum malaria in Hb-S and β-thalassaemia traits. Ann Trop Med Parasitol 77: 239–246Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • N. J. Choudhury
    • 1
  • M. L. Dubey
    • 2
  • J. G. Jolly
    • 1
  • Anju Kalra
    • 2
  • R. C. Mahajan
    • 2
  • N. K. Ganguly
    • 3
  1. 1.Department of Blood Transfusion and ImmunohaematologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of ParasitologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  3. 3.Department of Experimental MedicinePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Personalised recommendations