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Unchanged antigenic properties of a nuclear non-histone protein during phylogenesis

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The phyletic distribution of Sm antigen in eukaryotes has been investigated by means of immunochemical techniques. This nuclear antigen, which is an acidic glycoprotein of about 7S with DNA binding ability, is present in all organisms examined. Such evidence suggests a very slow evolutionary rate for at least the antigenic determinant(s) of the Sm antigen.

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Correspondence to Alessandro Ferracin.

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Nicotra, R., Natali, P. & Ferracin, A. Unchanged antigenic properties of a nuclear non-histone protein during phylogenesis. J Mol Evol 17, 256–258 (1981).

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Key words

  • Protein evolution
  • Nuclear proteins
  • Immunofluorescence