Journal of Molecular Evolution

, Volume 15, Issue 2, pp 161–168 | Cite as

Synthesis of peptides from amino acids and ATP with lysine-rich proteinoid

  • T. Nakashima
  • S. W. Fox


Lysine-rich proteinoids in aqueous solution catalyze the formation of peptides from free amino acids and ATP. This catalytic activity is not found in acidic proteinoids, even though the latter contain some basic amino acid. The pH optimum for the synthesis is about 11, but is appreciable below 8 and above 13. Temperature data indicate an optimum at 20°C or above, with little increase in rate to 60°C. Pyrophosphate can be used instead of ATP, with lesser yields resulting. The ATP-aided syntheses of peptides in aqueous solution occur with several types of proteinous amino acid.

Key words

Prebiotic synthesis Proteinoid Lysine-Rich ATP Pyrophosphate Peptides Cellular synthesis 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • T. Nakashima
    • 1
  • S. W. Fox
    • 1
  1. 1.Institute for Molecular and Cellular EvolutionUniversity of MiamiCoral GablesUSA

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