Journal of Molecular Evolution

, Volume 6, Issue 3, pp 185–197 | Cite as

Prebiotic peptide-formation in the solid state

III. Condensation Reactions of Glycine in Solid State Mixtures Containing Inorganic Polyphosphates
  • H. Sawai
  • L. E. Orgel


The reactions of glycine with inorganic polyphosphates in the solid state have been studied. The formation of peptides up to the decamer occurs at moderate temperatures (r.t.−100°C) in the presence of imidazole and magnesium chloride. If adenosine 5′-monophosphate is added to the reaction mixture, 2′(3′)-O-glycyl adenosine 5′-monophosphate is also obtained. These reactions could have occurred on the primitive earth.

Key words

Prebiotic Activation Peptides Inorganic Polyphosphates Trimetaphosphate Amino Acids 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Chung, N.M., Lohrmann, R., Orgel, L.E., Rabinowitz, J. (1971). Tetrahedron 27, 1205Google Scholar
  2. Feldmann, W. (1969). Z.Chem. 9, 145Google Scholar
  3. Greenstein, J.P., Winitz, M. (1961). Chemistry of the amino acids, Vol.2, p.921. New York: WileyGoogle Scholar
  4. Gottikh, B.P., Krayerskii, A.A., Tarussova, N.B., Purygin, P.P., Tsilevich, T.L. (1970). Tetrahedron 26, 4419Google Scholar
  5. Lohrmann, R., Ranganathan, R., Sawai, H., Orgel, L.E. (1975). J.Mol.Evol. 5, 57Google Scholar
  6. Lohrmann, R., Orgel, L.E. (1973). Nature 244, 418Google Scholar
  7. Osterberg, R., Orgel, L.E. (1972). J.Mol.Evol. 1, 241Google Scholar
  8. Rabinowitz, J. (1969). Helv.Chim.Acta 52, 2663Google Scholar
  9. Rabinowitz, J., Flores, J., Krebobach, R., Rogers, G. (1969). Nature 224, 796Google Scholar
  10. Rosenberg, H. (1969). Data for biochemical research, R.M.C. Dawson, D.C.Elliott, W.H. Elliott, K.M. Jones, eds., p.563. Oxford: Univ.PressGoogle Scholar
  11. Sawai, H., Lohrmann, R., Orgel, L.E. (1975). J.Mol.Evol. 6, 165Google Scholar
  12. Thilo, E., Schulz, G., Wichmann, E.M. (1953). Z.Anorg.Allgem.Chem. 272, 182Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • H. Sawai
    • 1
  • L. E. Orgel
    • 1
  1. 1.The Salk Institute for Biological StudiesSan DiegoUSA

Personalised recommendations