Molecular and Cellular Biochemistry

, Volume 6, Issue 2, pp 75–83

On the involvement of a glucose 6-phosphate transport system in the function of microsomal glucose 6-phosphatase

  • William J. Arion
  • Bruce K. Wallin
  • Alex J. Lange
  • Lawrence M. Ballas
General and Review Articles a. general articles

DOI: 10.1007/BF01732001

Cite this article as:
Arion, W.J., Wallin, B.K., Lange, A.J. et al. Mol Cell Biochem (1975) 6: 75. doi:10.1007/BF01732001

Summary

A model for microsomal glucose 6-phosphatase (EC 3.1.3.9) is presented. Glucose 6-phosphatase is postulated to be resultant of the coupling of two components of the microsomal membrane: 1) a glucose 6-phosphate — specific transport system which functions to shuttle the sugar phosphate from the cytoplasm to the lumen of the endoplasmic reticulum; and 2) a catalytic component, glucose-6-P phosphohydrolase, bound to the luminal surface of the membrane. A large body of existing data was shown to be consistent with this hypothesis. In particular, the model reconciles well-documented differences in the kinetic properties of the enzyme of untreated and modified microsomal preparations. Characteristic responses of the enzyme to changes in nutritional and hormonal states may be attributed to adaptations which alter the relative capacities of the transport and catalytic components.

Copyright information

© Dr. W. Junk b.v. Publishers 1975

Authors and Affiliations

  • William J. Arion
    • 1
  • Bruce K. Wallin
    • 1
  • Alex J. Lange
    • 1
  • Lawrence M. Ballas
    • 1
  1. 1.Department of Physiology, Biochemistry and Pharmacology, New York, State Veterinary CollegeCornell UniversityIthacaUSA
  2. 2.Welch Foods, Inc.WestfieldUSA

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