Klinische Wochenschrift

, Volume 63, Issue 8, pp 344–351 | Cite as

The pathophysiology of cholesterol metabolism in man

  • Ch. J. Packard
  • J. Shepherd
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Summary

The concentration of low density lipoprotein in human plasma depends on the balance between its rates of synthesis and catabolism. Although both processes appear to be independently regulated they occur side by side in the liver and may be linked via the activity of the high affinity low density lipoprotein receptor on hepatocyte membranes. Dietary changes such as cholesterol feeding or variation in fat content can promote synthesis of the lipoprotein without changing catabolism while other interventions (e.g. sequestrant resin therapy) have the opposite effect. These different responses may be explained on the basis of compartmentalisation of regulatory sterol pools in the liver cell.

Key words

Lipoprotein Receptors Drugs Hormones 

Abbreviations

apo

apolipoprotein

FH

familial hypercholesterolaemia

HDL

high density lipoproteins (d=1.063–1.21 kg/l)

HMG CoA reductase

3-hydroxy-3-methylglutaryl Coenzyme A reductase

IDL

intermediate density lipoproteins (d=1.006–1.019 kg/l)

LDL

low density lipoproteins (d=1.019–1.063 kg/l)

VLDL

very low density lipoproteins (d<1.006 kg/l)

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Ch. J. Packard
    • 1
  • J. Shepherd
    • 1
  1. 1.Department of BiochemistryRoyal InfirmaryGlasgow

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