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Infection

, Volume 21, Issue 4, pp 220–222 | Cite as

Alterations in bone turnover in HIV-positive patients

  • J. Hernández Quero
  • N. Ortega Centeno
  • M. Muñoz-Torres
  • Maria Angeles Martinez Pérez
  • J. M. de la Higuera Torres-Puchol
Originalia

Summary

Changes in mineral metabolism have recently been described in AIDS patients. To determine whether such changes affect bone turnover and bone mass, we studied 16 HIV-seropositive patients, classified according to Centers for Disease Control criteria, and 27 healthy controls. Biochemical markers of bone turnover and bone mineral density were analyzed. Serum concentrations of osteocalcin were abnormally low (0.5 ± 1.3 ng/ml) in HIV-seropositive patients, in comparison with the control group (2.98 ± 1.6 ng/ml) (p<0.05). Urinary calcium/creatinine ratio was also decreased in HIV-positive patients (0.10 ± 0.09 vs 0.14 ± 0.09) (p<0.05). In addition, bone mass was slightly lower in HIV-seropositive patients, although the difference was not statistically significant. The pathogenic mechanism of these alterations and their clinical relevance still remain unclear, and several factors may be implicated.

Keywords

Bone Mineral Density Bone Mass Bone Turnover Osteocalcin Mineral Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Veränderter Knochen-Turnover bei HIV-positiven Patienten

Zusammenfassung

Bei AIDS-Patienten bescriebene Veränderungen im Mineralhaushalt gaben Anlaß für Untersuchungen zum Knochen-Turnover und der Knochenmasse. 16 HIV-seropositive Patienten, die nach den Kriterien der Centers for Disease Control klassifiziert wurden und 27 gesunde Kontrollpersonen wurden einer Analyse biochemischer Marker des Knochen-Turnover und Untersuchungen zur Knochendichte unterzogen. Bei HIV-seropositiven Patienten fanden sich abnorm niedrige Serum-Osteocalcin-Spiegel (0,5 ± 1,3 ng/ml im Vergleich zu 2,98 ± 1,6 ng/ml; p<0,05 bei den Kontrollpersonen). Der Quotient von Kalzium/Kreatinin im Urin war mit 0,10 ± 0,09 gegenüber 0,14 ± 0.09 bei HIV-Positiven niederiger als bei Gesunden (p<0,05). Bei HIV-seropositiven Patienten fand sich eine etwas geringere Knochenmasse als bei Kontrollen, der Unterschied war jedoch nicht statistisch signifikant. Der Pathomechanismus dieser Veränderungen sowie ihre klinische Bedeutung sind noch ungeklärt. Es ist anzunehmen, daß es sich um multikausales Geschehen handelt.

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Copyright information

© MMV Medizin Verlag GmbH München 1993

Authors and Affiliations

  • J. Hernández Quero
    • 1
  • N. Ortega Centeno
    • 1
  • M. Muñoz-Torres
    • 1
  • Maria Angeles Martinez Pérez
    • 1
  • J. M. de la Higuera Torres-Puchol
    • 1
  1. 1.Infectious Disease Unit and Endocrinology Div., University of Granada Hospital, School of MedicineUniversity of GranadaGranadaSpain

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