During intravenous corticotropin-releasing factor stimulation tests we observed a deepening of the tidal volume in 35 patients. To investigate this presumed respiratory stimulation we measured respiratory parameters in 12 healthy male volunteers in a single-blind placebo-controlled trial. The intravenous 60-s infusion of 100 µg of human corticotropin-releasing factor induced a very potent respiratory stimulation in every subject: respiratory minute volume (mean ± S.D.) increased by 81% from 6.319±0.577 to 11.464±1.264 liters per min (P<0.001), whereas there was only a slight rise in the mean respiratory rate from 12.4±3.0 to 14.7±2.7 breaths per min (P<0.001). Mean tidal volume increased from 531±105 to 809±175 ml (P<0.001). Mean end-tidal partial pressure of carbon dioxide decreased (P<0.001) from 40.3±1.2 to 33.4±1.2 mmHg, whereas mean end-tidal partial pressure of oxygen increased (P<0.001) from 93.2±5.4 to 113.5±5.4 mmHg. After 10 to 20 min both end-tidal carbon dioxide and oxygen partial pressures returned to the baseline values. The placebo had no measurable effects.
We conclude that human corticotropin-releasing factor is a potent respiratory stimulant. With 100 µg the resting respiratory minute volume increases by 81%. These data point to the possible importance of the corticotropin-releasing factor as a useful adjunct in the management of patients with alveolar hypoventilation.
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human corticotropin-releasing factor
- PETCO2 :
end-tidal partial pressure of carbon dioxide (the last portion of the VT during expiration, called end-tidal volume, contains CO2 from the alveolar region)
- PETO2 :
end-tidal partial pressure of oxygen
- \(\dot V_E \) :
- VT :
respiratory tidal volume
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Cite this article
Oppermann, D., Huber, I., Nink, M. et al. Human corticotropin-releasing factor (hCRF) is a potent respiratory analeptic. Klin Wochenschr 64, 924–928 (1986). https://doi.org/10.1007/BF01728617
- Human corticotropin-releasing factor (hCRF)
- Biological activity
- Respiratory analeptic
- Human beings