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Der Nachweis von HIV-1-Antigen — Bestimmung mit Hilfe von drei verschiedenen Testsystemen

Detection of HIV-1-antigen by using three different enzyme immunoassays

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Summary

51 human sera containing antibodies to human immunodeficiency virus 1 (=HIV-1) were examined for HIV-1-antigen by three different enzyme immunoassay procedures (=EIA) of Abbott, Organon and Dupont. Sensibilities, handling as well as the correlation with the clinical stages of HIV-infection were compared. The EIA's diagnosed in accordance 6 sera which contained HIV-1-antigen and 42 sera to be HIV-1-antigen negative. 3 sera showed differences: according to the EIA of Organon none of these sera contained HIV-1-antigen, the EIA of Abbott (but not of Dupont) analysed HIV-1-antigen in one of these sera, in the other two sera only the EIA of Dupont showed HIV-1-Antigen.

It is concluded that the differences in these 3 serum samples may originate not only in the different types of EIA used (indirect/direct procedure) but also in the different capture antibodies provided (antibodies against p-24 antigen or polyvalent antibodies).

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Abbreviations

HIV-1:

human immunodeficiency virus

AIDS:

acquired immunodeficiency syndrome

EIA:

enzyme immunoassay

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Authors and Affiliations

  1. Institut für Medizinische Mikrobiologie und Hygiene, Germany

    F. Düzgün & N. Dickgießer

  2. I. Medizinische Klinik, Germany

    D. Schuster

  3. II. Medizinische Klinik, Germany

    J. Teuber

  4. III. Med. Klinik, Klinikum der Stadt Mannheim, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim

    E. Lengfelder

Authors
  1. F. Düzgün
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  2. N. Dickgießer
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  3. D. Schuster
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  4. E. Lengfelder
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  5. J. Teuber
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Düzgün, F., Dickgießer, N., Schuster, D. et al. Der Nachweis von HIV-1-Antigen — Bestimmung mit Hilfe von drei verschiedenen Testsystemen. Klin Wochenschr 66, 212–215 (1988). https://doi.org/10.1007/BF01728199

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  • DOI: https://doi.org/10.1007/BF01728199

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