Klinische Wochenschrift

, Volume 62, Issue 12, pp 564–569 | Cite as

Fluorine and thyroid gland function: A review of the literature

  • H. Bürgi
  • L. Siebenhüner
  • E. Miloni


The increasing use of fluoride for prevention of dental caries poses the problem as to whether this halogen has antagonistic properties towards iodine, whereby it could hamper the success of iodine prophylaxis of endemic goitre. Review of the literature shows that some authors have found an inhibition by fluoride of various steps of thyroid hormone biosynthesis in animal experiments. By and large, the inhibition was only slight and it was elicited only with fluoride doses greatly in excess of those recommended for caries prevention. The inhibition was not consistently present and other authors could not confirm it in comparable experiments. There is no convincing evidence that fluoride produces true goitres with epithelial hyperplasia in experimental animals. There are some reports based on casual observations that fluoride is goitrogenic in man. On the other hand, several good studies with adequate exposed and control populations failed to detect any goitrogenic effect of fluoride in man. It is noteworthy in particular that fluoride does not potentiate the consequences of iodine deficiency in populations with a borderline or low iodine intake. Published data fail to support the view that fluoride, in doses recommended for caries prevention, adversely affects the thyroid.

Key words

Fluorine Thyroid gland Goitre 


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  1. 1.
    Ahn CS, Rosenberg IN (1970) Iodine metabolism in thyroid slices — effects of TSH, dibutyril cyclic 3′,5′-AMP, NaF and prostaglandin E1. Endocrinology 86:396–405Google Scholar
  2. 2.
    Auskaps AM, Shaw JH (1955) Hemoglobin concentration, thyroid weight and growth rate in rats during minimum fluoride ingestion. J Nutr 55:611–621Google Scholar
  3. 3.
    Benagiano P (1957) Prophylaxie de la carie et fluor. Rev Fr Odonto-Stomatol 4:1286–1296Google Scholar
  4. 4.
    Bobek S, Kahl S, Ewy Z (1976) Effect of long-term fluoride administration on thyroid hormone levels in rats. Endocrinol Exp (Bratisl) 10:289–295Google Scholar
  5. 5.
    Chaneles J (1929) Action de l'iode sur la fluorose chronique. Compt Rend Soc Biol (Paris) 102:863Google Scholar
  6. 6.
    Chang CY, Phillips PH, Hart EB (1934) The effect of feeding raw rock phosphate on the fluorine content of the organs and tissues of dairy cows. J Dairy Sci 17:695–700Google Scholar
  7. 7.
    Cristiani H (1930) Altération de la glande thyroïde dans l'intoxication fluorée. Compt Rend Soc Biol 103:554–556Google Scholar
  8. 8.
    Day TK, Powell-Jackson PR (1972) Fluoride, water hardness and endemic goitre. Lancet I:1135–1138Google Scholar
  9. 9.
    Demole V (1951) Iode, fluor, thyroïde chez les écoliers en Suisse. Bull Schweiz Akad Med Wiss 7:430–439Google Scholar
  10. 10.
    Demole V, von Fellenberg Th, Held AJ, Schmid H (1951) Fluor, carie dentaire et thyroîde. Bull Schweiz Akad Med Wiss 7:440–462Google Scholar
  11. 11.
    Demole V, Lerch P (1956) Normalité du dépot d'iode 131 dans thyroïde du rat au cours de la fluorose expérimentalc. Helv Physiol Pharmacol Acta 14:C62-C63Google Scholar
  12. 12.
    Demole V (1970) Toxic effects on the thyroid. In: Fluorides and Human Health. WHO-Monograph, Geneva, pp 255–262Google Scholar
  13. 13.
    Dolci G, D'Angelo G, D'Antonio A (1966) Considerazioni su alcuni casi di disfunzione tiroidea in individui abitanti in zona altamente fluorotica. Ann Stomatol 24:273–276Google Scholar
  14. 14.
    Evans RJ, Phillips PH (1938) The fluorine content of the thyroid gland in cases of hyperthyroidism. J Am Med Assoc 111:300–302Google Scholar
  15. 15.
    von Fellenberg T (1938) Besteht ein Zusammenhang zwischen Fluorgehalt des Trinkwassers und Kropf? Mitteil Lebensmitteluntersuchungen und Hygiene (Berne) 29:276–290Google Scholar
  16. 16.
    Galletti PM, Joyet G, Jallut O (1957) Effets du fluorure de sodium sur la fonction thyroïdienne dans la maladie de Basedow. Helv Med Acta 24:209–215Google Scholar
  17. 17.
    Galletti PM, Joyet G (1958) Effect of fluorine on thyroidal iodine metabolism in hyperthyroidism. J Clin Endocrinol 18:1102–1110Google Scholar
  18. 18.
    Gedalia I, Gross J, Guttman S, Steiner JE, Sulman FG, Weinreb MM (1960) The effects of water fluorination on thyroid function, bones and teeth of rats on a low iodine diet. Arch Intern Pharmacodyn 129:116–124Google Scholar
  19. 19.
    Goldenberg L (1926) Action physiologique des fluorures. Compt Rend Soc Physiol (Paris) 95:1169Google Scholar
  20. 20.
    Gordonoff T (1957) Zum Fluorproblem. Osterr Z Stomatol 54:561–571Google Scholar
  21. 21.
    Gordonoff T, Minder W (1960) Fluorine and the thyroid gland. In “World Review of Nutrition and Dietetics”. Pitman Medical Co, Vol 2:234–247Google Scholar
  22. 22.
    Gorlitzer von Mundy V (1963) Einfluss von Fluor und Jod auf den Stoffwechsel, insbesondere auf die Schilddrüse. Munch Med Wochenschr 105:182–186Google Scholar
  23. 23.
    Harris NO, Hayes RL (1955) A tracer study of the effect of acute and chronic exposure to sodium fluoride on the thyroid iodine metabolism of rats. J Dent Res 34:470–477Google Scholar
  24. 24.
    Hatfield JD, Shrewsbury CL, Andrews FN, Doyle LP (1944) Iodine-fluorine relationships in sheep nutrition. J Anim Sci 3:71–77Google Scholar
  25. 25.
    Hein JW, Bonner JF, Brudevold F, Smith FA, Hodge HC (1956) Distribution in the soft tissue of the rat of radioactive fluoride administered as sodium fluoride. Nature 175:1295–1296Google Scholar
  26. 26.
    Held AJ (1953) Fluor et glande thyroïde. Bull Schweiz Akad Med Wiss 9:132–145Google Scholar
  27. 27.
    Henning K, Fritz H (1961) Fluor und Schilddrüse. Schweiz Med Wochenschr 91:79–81Google Scholar
  28. 28.
    Hetzel BS (1983) Iodine deficiency disorders (IDD) and their eradication. Lancet II:1126–1129Google Scholar
  29. 29.
    Hoffmann-Axthelm W (1953) Beobachtungen über den Einfluß des Fluors auf Zahnschmelz und Schilddrüse. Dtsch Zahnaerztl Z 8:757–765Google Scholar
  30. 30.
    Holland RI, Hongslo JK, Christofferson Th (1980) On the role of cyclic AMP in the cytotoxic effect of fluoride. Acta Pharmacol Toxicol 46:66–72Google Scholar
  31. 31.
    Jentzer A (1954) Action du fluor sur le relais thyroïdienhypophysaire démontrée par l'iode 131. Bull Schweiz Akad Med Wiss 10:211–220Google Scholar
  32. 32.
    Jentzer A (1959) Effet du fluor et du fluor-iode sur la teneur en iode de la thyroïde de lapin. Bull Schweiz Akad Med Wiss 15:412–422Google Scholar
  33. 33.
    Kahl S, Bobek S (1975) Effect of fluoride administration on radiothyroxine turnover in rats. Endocrynol Pol 26:391–398Google Scholar
  34. 34.
    Korrodi H, Wegmann T, Galletti P, Held HR (1955) Sind bei der Cariesprophylaxe mit Fluor Rückwirkungen auf die Schilddrüse zu erwarten? Schweiz Med Wochenschr 85:1016–1019Google Scholar
  35. 35.
    Korrodi H, Wegmann T, Galletti P, Held HR (1956) Fluor und Schilddrüse. Z Praeventivmed 1:285–296Google Scholar
  36. 36.
    Leone NC, Leatherwood DC, Petrie IM, Lieberman L (1964) Effect of fluoride on thyroid gland: clinical study. J Am Dent Assoc 69:179–180Google Scholar
  37. 37.
    Levi JE, Silberstein HE (1955) Lack of effect of fluorine ingestion on uptake of iodine131 by the thyroid gland. J Lab Clin Med 45:348–351Google Scholar
  38. 38.
    Litzka G (1937) Die experimentellen Grundlagen der Behandlung des M. Basedow und der Hyperthyreose mittels Fluortyrosin. Dtsch Med Wochenschr 63:1037–1040Google Scholar
  39. 39.
    Maumené E (1854) Expérience pour déterminer l'action des fluorures sur l'économie animale. Compt Rend Acad Sci (Paris) 39:538–539Google Scholar
  40. 40.
    Maumené E (1866) Recherches expérimentales sur les causes du goître. Compt Rend Acad Sci (Paris) 62:381–383Google Scholar
  41. 41.
    May W (1935) Antagonismus zwischen Fluor und Jod im Organismus. Klin Wochenschr 14:790–792Google Scholar
  42. 42.
    May W (1937) Behandlung der Hyperthyreosen einschließlich des schweren genuinen Morbus Basedow mit Fluor. Klin Wochenschr 16:562–564Google Scholar
  43. 43.
    McLaren JR (1976) Possible effects of fluorides on the thyroid. Fluoride 9:105–116Google Scholar
  44. 44.
    Minder W, Gordonoff T (1956) An antagonism between iodine and fluorine. Arch Intern Pharmacodyn 107:374–381Google Scholar
  45. 45.
    Mühlemann HR, Schneider R (1956) Die mitotische Aktivität des Schilddrüsenepithels der Ratte bei Verabreichung von fluoridiertem Trinkwasser. Schweiz Med Wochenschr 86:625–627Google Scholar
  46. 46.
    Narbutt B, Romer TE, Grabski J, Szymik N (1971) Influence of sodium fluoride on structure of rat thyroids (in Polish). Endokrynol Pol 12:445–450Google Scholar
  47. 47.
    Ogilvie AL (1953) Histologic findings in the kidney, liver, pancreas, adrenal, and thyroid glands of the rat following sodium fluoride administration. J Dent Res 32:386–397Google Scholar
  48. 48.
    Pastan I, Macchia V, Katzen R (1968) Effect of fluoride on metabolic activity of thyroid slices. Endocrinology 83:157–160Google Scholar
  49. 49.
    Phillips PH, English HE, Hart EB (1935) The influence of sodium fluoride upon the basal metabolism of the rat under several experimental conditions. Am J Physiol 113:441–449Google Scholar
  50. 50.
    Phillips PH (1936) Further studies on the effects of NaF administration upon the basal metabolic rate of experimental animals. Am J Physiol 117:155–159Google Scholar
  51. 51.
    Rodesch F, Neve P, Willems C, Dumont JE (1969) Stimulation of thyroid metabolism by thyrotropin, cyclic 3′-5′-AMP, dibutyryl cyclic 3′-5′-AMP and prostaglandin E1. Eur J Biochem 8:26–32Google Scholar
  52. 52.
    Schweiz Akademie der Medizinischen Wissenschaften (1981) Kariesprophylaxe durch Fluoridanwendung. Schweiz Aerztezeitung 62:1904Google Scholar
  53. 53.
    Siddiqui AH (1960) Incidence of simple goitre in areas of endemic fluorosis. J Endocrinol 20:101–105Google Scholar
  54. 54.
    Siebenhüner L, Miloni E, Bürgi H (1984) Effects of fluoride on thyroid hormone biosynthesis. Studies in a highly sensitive test system. Klin Wochenschr (in press)Google Scholar
  55. 55.
    Steyn DG (1948) Fluorine and endemic goitre. S Afr Med J 22:525–526Google Scholar
  56. 56.
    Stolc V, Podoba J (1960) Effect of fluoride on the biogenesis of thyroid hormones. Nature 188:855–856Google Scholar
  57. 57.
    Stormont J, Kozelka FL, Seevers MH (1931) The iodine content of the thyroid following chronic fluoride administration. J Pharmacol Exp Ther 57:143–144Google Scholar
  58. 58.
    Wadhwani TK (1953) Metabolism of fluorine. Absorption, retention, distribution and elimination of fluorine and its effect on the vitamin C content of different tissues, and on the iodine content of thyroids of rats and monkeys. J Indian Inst Sci 35:354–362Google Scholar
  59. 59.
    Wallace-Durbin P (1954) The metabolism of fluorine in the rat using18F as a tracer. J Dent Res 33:789–800Google Scholar
  60. 60.
    Wespi HJ (1954) Besteht ein Antagonismus zwischen Fluor und Jod? Praxis 43:616–623Google Scholar
  61. 61.
    Wespi HJ (1955) Analyse des Wirkungsmechanismus eines möglichen Antagonismus zwischen Jod und Fluor. Schweiz Monatsschr Zahnheilkunde 65:745–753Google Scholar
  62. 62.
    Wespi-Eggenberger HJ (1960) Investigations about the effect of the thyroid gland of the newborn of a general and an individual prophylaxis in pregnant women by means of an iodized and iodized fluoridated common salt with varying dosages. J Indian Med Profession 7:3281–3286Google Scholar
  63. 63.
    WHA Report A 31/50 (1978) Resolution of the 31st World Health Assembly, Geneva, May 24Google Scholar
  64. 64.
    Willems C, Berberof-Van Sande J, Dumont JE (1972) Inhibition of thyroid secretion by sodium-fluoride in vitro. Biochim Biophys Acta 264:197–204Google Scholar
  65. 65.
    Williams RH, Jaffe H, Soloman B (1950) Effect of halides on the antithyroid action of thiouracil and prophylthiouracil. Am J Med Sci 219:1–6Google Scholar
  66. 66.
    Wilson DC (1941) Fluorine in aetiology of endemic goitre. Lancet I:211–213Google Scholar
  67. 67.
    Wolff J (1964) Transport of iodide and other anions in the thyroid gland. Physiol Rev 44:45–90Google Scholar
  68. 68.
    Zor U, Kaneko T, Lowe IP, Bloom G, Field JB (1969) Effect of thyroid-stimulating hormone and prostaglandins on thyroid adenyl cyclase activation and cyclic adenosin 3′-5′-monophosphate. J Biol Chem 244:5189–5195Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • H. Bürgi
    • 1
  • L. Siebenhüner
    • 1
  • E. Miloni
    • 1
  1. 1.Medizinische Klinik am BürgerspitalSolothurn und Laboratorium für Endokrinologie der Medizinischen Universitätsklinik InselspitalBernSchweiz

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