Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Dosierung der intrakoronaren Urokinase-Infusion beim akuten Myokardinfarkt

Dosage of intracoronary urokinase-infusion in acute myocardial infarction

  • 16 Accesses


In 11 patients with acute myocardial infarction (mean age 52±6 years) coronary angiography was performed 4.5±3.6 h after the onset of symptoms. The infarct-related artery was in 7 cases the right coronary artery and in 4 cases the left anterior descending branch of the left coronary artery. The infarct-related artery showed total or subtotal occlusion and no perfusion (Thrombolysis in Myocardial Infarction trial (TIMI) grade 0 or 1). In 7 cases Urokinase was infused intracoronarily at a dosage of 250 000 IU over 30 min, but in only 1 case partial reperfusion was achieved. However, all patients treated with 500 000 IU Urokinase over 30 min or 1 Mill IU over 60 min had successful reperfusion (TIMI grade 2 or 3). Thus, it appears that 500 000 IU up to 1 Mill IU of Urokinase over a period of 30 to 60 min is adequate for intracoronary thrombolysis in patients with acute myocardial infarction.

This is a preview of subscription content, log in to check access.

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.



Thrombolysis in Myocardial Infarction trial


Perkutane transluminale Koronarangioplastie


rechte Koronararterie


Ramus interventrikularis anterior


Internationale Einheiten




  1. 1.

    Cernigliaro C, Sansa M, Campi A, Bongo AS, Rossi P (1987) Clinical experience with Urokinase in intracoronary thrombolysis. Clin Cardiol 10:222–230

  2. 2.

    De Wood MA, Spores J, Notske R, Mouser LT, Burroughs R, Golden MS, Lang HT (1980) Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 303:897–902

  3. 3.

    Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI). Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1986 1:397–402

  4. 4.

    Kambara H, Kawai C, Kammatsuse H, Sato H, Nobuyoshi M, Chino M, Miwa H, Uchida V, Kodama K, Mitsudo K, Hayashi T, Kajiwara N, Sekiguchi M, Yasme H (1985) Coronary thrombolysis with urokinase infusion in acute myocardial infarction: Multicenter study in Japan. Cathet Cardiovasc Diag 11:349–360

  5. 5.

    Kambara H, Kammatsuse K, Nobuyoshi M, Kodama K, Sato H, Sasayama S, Kajiwara N, Nakashima M, Kawai C (1987) Randomized double-blind trial of intracoronary urokinase for acute myocardial infarction: Multicenter study. Jap Circulat J 51:1072–1076

  6. 6.

    Marder VJ, Sherry S (1988) Thrombolytic therapy: Current status (First of two parts) N Engl J Med 318:1512–1520

  7. 7.

    Marder VJ, Sherry S (1988) Thrombolytic therapy: Current status (Second of two parts) N Engl J Med 318:1585–1595

  8. 8.

    Mathey DG, Schofer J, Sheehan FH, Becher H, Tilsner V, Dodge HT (1985) Intravenous Urokinase in acute myocardial infarction. Am J Cardiol 55:878–882

  9. 9.

    Neuhaus KL, Tebbe U, Weber MAJ, Gottwik MG (1987) Thrombolysis in acute myocardial infarction: results of the German-Activator-Urokinase-Study (GAUS). Circulation 76:Suppl 4:IV-121

  10. 10.

    Ohyagi A, Hirose K, Watanabe Y, Nakai T, Tsujimoto S, Doyama K, Suzuki Y, Okazaki S, Hirai M (1987) Dose of urokinase for intracoronary thrombolysis in patients with acute myocardial infarction. Clin Cardiol 10:453–456

  11. 11.

    Schröder R, Neuhaus KL, Leizorovicz A, Linderer T, Tebbe U for the ISAM Study Group (1986) A prospective trial of intravenous streptokinase in acute myocardial infarction (ISAM): mortality, morbidity, and infarct size at 21 days. N Engl J Med 314:1465–1471

  12. 12.

    Tennant S, Dixon J, Venable TC, Pageja HL, Roach A, Kaiser BA, Frederiksen R, Tacogue L, Kaplan P, Babu NS, Anderson EE, Wooden E, Jennings HS, Breining J, Campbell WB (1984) Intracoronary thrombolysis in patients with acute myocardial infarction: Comparison of the efficacy of urokinase with streptokinase. Circulation 69:756–760

  13. 13.

    The TIMI Study Group (1985) The Thrombolysis in Myocardial Infarction (TIMI) trial: Phase I findings. N Engl J Med 312:932–936

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tebbe, U., Herrmann, K.S. Dosierung der intrakoronaren Urokinase-Infusion beim akuten Myokardinfarkt. Klin Wochenschr 66, 1193–1195 (1988). https://doi.org/10.1007/BF01727669

Download citation

Key words

  • Coronary thrombolysis
  • Urokinase
  • Acute myocardial infarction