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Dosierung der intrakoronaren Urokinase-Infusion beim akuten Myokardinfarkt

Dosage of intracoronary urokinase-infusion in acute myocardial infarction

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Summary

In 11 patients with acute myocardial infarction (mean age 52±6 years) coronary angiography was performed 4.5±3.6 h after the onset of symptoms. The infarct-related artery was in 7 cases the right coronary artery and in 4 cases the left anterior descending branch of the left coronary artery. The infarct-related artery showed total or subtotal occlusion and no perfusion (Thrombolysis in Myocardial Infarction trial (TIMI) grade 0 or 1). In 7 cases Urokinase was infused intracoronarily at a dosage of 250 000 IU over 30 min, but in only 1 case partial reperfusion was achieved. However, all patients treated with 500 000 IU Urokinase over 30 min or 1 Mill IU over 60 min had successful reperfusion (TIMI grade 2 or 3). Thus, it appears that 500 000 IU up to 1 Mill IU of Urokinase over a period of 30 to 60 min is adequate for intracoronary thrombolysis in patients with acute myocardial infarction.

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Abbreviations

TIMI:

Thrombolysis in Myocardial Infarction trial

PTCA:

Perkutane transluminale Koronarangioplastie

RCA:

rechte Koronararterie

RIVA:

Ramus interventrikularis anterior

IE:

Internationale Einheiten

min:

Minuten

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Tebbe, U., Herrmann, K.S. Dosierung der intrakoronaren Urokinase-Infusion beim akuten Myokardinfarkt. Klin Wochenschr 66, 1193–1195 (1988). https://doi.org/10.1007/BF01727669

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Key words

  • Coronary thrombolysis
  • Urokinase
  • Acute myocardial infarction