Klinische Wochenschrift

, Volume 65, Issue 12, pp 542–545 | Cite as

Intracranial flow patterns at increasing intracranial pressure

  • J. Klingelhöfer
  • B. Conrad
  • R. Benecke
  • D. Sander


In the course of a pilot study, changes in intracranial pressure were compared with the transcranial Doppler findings of the middle cerebral artery. The cases of five patients were discussed who developed dissociated brain death in spite of intensive therapeutic measures. The studies showed that changes of the intracranial pressure influenced the flow patterns considerably: at increasing intracranial pressure (decreasing cerebral perfusion pressure) a progressive reduction of the systolic and above all diastolic flow velocities and finally a pendular flow occurred. These changes could be recorded quantitatively by means of the “Pourcelot index” and the mean flow velocity. Acute changes of the intracranial pressure can be detected at an early stage by noninvasive transcranial Doppler studies and can be followed by adequate intensive therapy.

Key words

Transcranial Doppler Intracranial pressure Cerebral diseases 



Mean cerebral perfusion pressure


Intracranial pressure


Mean systemic arterial pressure


Middle cerebral artery


Mean flow velocity


Carbon dioxide tension


Index de résistance=Pourcelot index


Transcranial Doppler


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • J. Klingelhöfer
    • 1
  • B. Conrad
    • 1
  • R. Benecke
    • 1
  • D. Sander
    • 1
  1. 1.Abteilung Klinische NeurophysiologieGeorg-August-Universität GöttingenGermany

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