Klinische Wochenschrift

, Volume 67, Issue 8, pp 456–462 | Cite as

Plasma-Katecholamin-Verlauf bei Alkylphosphat-Intoxikationen und deren Therapie

  • G. Kauert
  • B. Schoppek
  • M. v. Clarmann
  • A. Hibler
Kasuistiken
Received:
Revised:
Accepted:

Abkürzungsverzeichnis

Amp.

Ampulle

ChE

Cholinesterase

HPLC

High pressure liquid chromatography (Hochdruckflüssig-Chromatographie)

Li

Lithium

m-Rezeptoren

muskarinische Rezeptoren

n-Rezeptoren

nikotinische Rezeptoren

®

eingetragenes Warenzeichen

ZVD

Zentraler Venendruck

Plasma catecholamine kinetics in the course of organophosphate-poisonings and their therapy

Summary

In connection with the “endogenous acetylcholine-poisoning” due to organophosphorous compounds beside the clinical important muscarinic and nicotinic symptoms an activation of the sympathetic nervous system (adrenal medulla, sympathetic ganglia) is expected. Therefore a kinetic profile of norepinephrine and epinephrine in the plasma of two patients with severe parathionpoisonings was taken up through the whole period of the intensive-medical treatment. The method used was HPLC with electrochemical detection. The parathion-concentration of the same plasma samples were measured, too. The result were individual different courses with periodically appearing, markedly increased plasma catecholamine values. A direct correlation of catecholamines with the parathion-concentration was not recognizable. A possible influence of the atropine-treatment as well as of stress-factors is discussed but estimated as not responsible for the observed peaks.

Key words

Plasma catecholamines Norepinephrine Epinephrine Organophosphate poisoning 
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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • G. Kauert
    • 1
  • B. Schoppek
    • 1
  • M. v. Clarmann
    • 2
  • A. Hibler
    • 2
  1. 1.Institut für Rechtsmedizin der Universität MünchenGermany
  2. 2.Toxikologische Abteilung des Klinikums rechts der Isar der Technischen Universität MünchenGermany

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