Virus Genes

, Volume 10, Issue 1, pp 53–71 | Cite as

Functional organization of variola major and vaccinia virus genomes

  • Sergei N. Shchelkunov
Article

Abstract

Comparison of the genomic organization of variola and vaccinia viruses has been carried out. Molecular factors of virulence of these viruses is the focus of this review. Possible roles of the genes of soluble cytokine receptors, complement control proteins, factors of virus replication, and dissemination in vivo for variola virus pathogenesis are discussed. The existence of “buffer” genes in the vaccinia virus genome is proposed.

Key words

smallpox orthopoxvirus variola virus vaccinia virus molecular factors of virulence 

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References

  1. 1.
    Fenner F., Wittek, R., and Dumbell K.R.,The Orthopoxviruses. Academic Press, San Diego, CA, 1989, p. 432.Google Scholar
  2. 2.
    Moss B., in Binns M.M. and Smith G.L. (eds).Recombinant Poxviruses. CRC Press, London, 1992, pp. 45–80.Google Scholar
  3. 3.
    Zhang Y., Ahn B.-Y., and Moss B., J Virol68, 1360–1370, 1994.Google Scholar
  4. 4.
    Schnierle B.S., Gershon P.D., and Moss B., Proc Natl Acad Sci USA89, 2897–2901, 1992.Google Scholar
  5. 5.
    Shuman S., Broyles S.S., and Moss B., J Biol Chem262, 12372–12380, 1987.Google Scholar
  6. 6.
    Vos J.C., Sasker M., and Stunnenberg H.G., EMBO J10, 2553–2558, 1991.Google Scholar
  7. 7.
    Carpenter M.S. and DeLange A.M., J Virol65, 4042–4050, 1991.Google Scholar
  8. 8.
    Moss B., Ahn B.-Y., Amegadzie B., Gershon P.D., and Keck J.G., J Biol Chem266, 1355–1358, 1991.Google Scholar
  9. 9.
    Parsons B.L. and Pickup D.J., Virology175, 69–80, 1990.Google Scholar
  10. 10.
    Stuart D., Graham K., Schreiber M., Macaulay C., and McFadden G., J Virol65, 61–70, 1991.Google Scholar
  11. 11.
    Moyer R.W., Virus Res8, 173–191, 1987.Google Scholar
  12. 12.
    Tamin A., Esposito J., and Hruby D., Virology182, 393–396, 1991.Google Scholar
  13. 13.
    Yuwen H., Cox J.H., Yewdell J.W., Bennink J.R., and Moss B., Virology195, 732–744, 1993.Google Scholar
  14. 14.
    Rosales R., Sutter G., and Moss B., Proc Natl Acad Sci USA91, 3794–3798, 1994.Google Scholar
  15. 15.
    Jindal S. and Young R.A., J Virol66, 5357–5362, 1992.Google Scholar
  16. 16.
    Hendrick J.P. and Hartl F.-U., Annu Rev Biochem62, 349–384, 1993.Google Scholar
  17. 17.
    Moss B., in Fields B.N., Knipe D.M., Chanock R.M., Hirsch M.S., Melnick J., Monath T.P., and Roizman B. (eds).Virology. Raven Press, New York, 1990, pp. 2079–2112.Google Scholar
  18. 18.
    Wright C.F. and Coroneos A.M., J Virol67, 7264–7270, 1993.Google Scholar
  19. 19.
    Kovacs G.R., Rosales R., Keck, J.G., and Moss B., J Virol68, 3443–3447, 1994.Google Scholar
  20. 20.
    Sodeik B., Doms R.W., Ericsson M., Hiller G., Machamer C.E., van't Hof W., van Meer G., Moss B., and Griffiths G., J Cell Biol121, 521–541, 1993.Google Scholar
  21. 21.
    Dubochet J., Adrian M., Richter K., Garces J., and Wittek R., J Virol68, 1935–1941, 1994.Google Scholar
  22. 22.
    Lee P. and Hruby D.E., J Virol67, 4252–4263, 1993.Google Scholar
  23. 24.
    Schmeltz M., Sodeik B., Ericson M., Wolffe E.J., Shida H., Hillert G., and Griffiths G., J Virol68, 130–147, 1994.Google Scholar
  24. 25.
    Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., and Paoletti E., Virology179, 247–266, 1990.Google Scholar
  25. 26.
    Shchelkunov S.N., Marennikova S.S., Blinov V.M., Resenchuk S.M., Totmenin A.V., Chizhikov V.E., Gutorov V.V., Safronov P.F., Kurmanov R.K., and Sandakhchiev L.S., Doklady Akademii Nauk328, 629–632, 1993 (in Russian).Google Scholar
  26. 27.
    Shchelkunov S.N., Resenchuk S.M., Totmenin A.V., Blinov V.M., Marennikova S.S., and Sandakhchiev L.S., FEBS Lett327, 321–324, 1993.Google Scholar
  27. 28.
    Massung R.F., Esposito J.J., Liu L., Qi J., Utterback T.R., Knight J.C., Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A., Cavallaro K.F., Keriavage A.R., Mahy B.W., and Venter J.C., Nature366, 748–751, 1993.Google Scholar
  28. 29.
    Massung R.F., Liu L.-I., Qi J., Knight J.C., Yuran T.E., Kerlavage A.R., Parsons J.M., Venter J.C., and Esposito J.J., Virology201, 215–240, 1994.Google Scholar
  29. 31.
    Johnson G.P., Goebel S.J., and Paoletti E., Virology196, 381–401, 1993.Google Scholar
  30. 32.
    Shchelkunov S.N., Blinov V.M., and Sandakhchiev L.S., FEBS Lett319, 80–83, 1993.Google Scholar
  31. 33.
    Shchelkunov S.N., Blinov V.M., and Sandakhchiev L.S., FEBS Lett319, 163–165, 1993.Google Scholar
  32. 34.
    Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V., and Sandakhchiev L.S., Virus Res30, 239–258, 1993.Google Scholar
  33. 35.
    Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S., Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gutorov V.V., Gashnikov P.V., Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G., and Sandakhchiev L.S., Virus Res27, 25–35, 1993.Google Scholar
  34. 36.
    Shchelkunov S.N., Resenchuk S.M., Totmenin A.V., Blinov V.M., and Sandakhchiev L.S., Virus Res32, 37–55, 1994.Google Scholar
  35. 37.
    Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V., Olenina L.V., Chirikova G.B., and Sandakhchiev L.S., Virus Res, 1994, in press.Google Scholar
  36. 38.
    Moyer R.W. and Turner P.C., Curr Top Microbiol Immunol163, 125–151, 1987.Google Scholar
  37. 39.
    Buller R.M.L. and Palumbo G.J., Microbiol Rev55, 80–122, 1991.Google Scholar
  38. 40.
    Smith G.L., J Gen Virol74, 1725–1740, 1993.Google Scholar
  39. 41.
    Senkevich T.G., Koonin E.V., and Buller R.M.L., Virology198, 118–128, 1994.Google Scholar
  40. 42.
    Shchelkunov S.N. and Blinov V.M., FEBS Lett335, 138, 1993.Google Scholar
  41. 43.
    Shchelkunov S.N., Blinov V.M., Totmenin A.V., Chizhikov V.E., Olenina L.V., Gutorov V.V., Safronov P.F., Sandakhchiev L.S., Marennikova S.S., Andzhaparidze O.G., Li-Ing L., Utterbach T., Kerlavage A., Selivanov N., Venter J.C., Esposito J.J., Massung R.F., Jin Q., Knight J.C., Loparev V., Cavallaro K.F., Yuran T.E., Parsons J.M., and Mahy B.W.J., in Mahy B.W.J. and Lvov D.K. (eds.).Concepts in Virology: From Ivanonsky to the Present. Harwood Academic Publishers, Singapore, 1993, pp. 93–106.Google Scholar
  42. 44.
    Porter A.G., Trends Biotechnol9, 158–162, 1991.Google Scholar
  43. 45.
    Thornberry N.A., Nature370, 251–252, 1994.Google Scholar
  44. 46.
    Tracey K.J. and Cerami A., Annu Rev Med45, 491–503, 1994.Google Scholar
  45. 47.
    Martin M. and Resch K., Trends Pharmacol Sci9, 171–177, 1988.Google Scholar
  46. 48.
    Mestan J., Diegel W., Mittnacht S., Hillen H., Blohm D., Moller A., Jacobsen H., and Kirchner H., Nature323, 816–818, 1986.Google Scholar
  47. 49.
    Wong G.H.W. and Goeddel D. V., Nature323, 819–822, 1986.Google Scholar
  48. 50.
    Wille A., Gessner A., Lother H., and Lehmann-Grube F., Eur J Immunol19, 1283–1289, 1989.Google Scholar
  49. 51.
    Ramshaw I., Ruby J., Ramsay A., Ada G., and Karupiah G., Immunol Rev127, 157–182, 1992.Google Scholar
  50. 52.
    Melkova Z. and Esteban M., Virology198, 731–735, 1994.Google Scholar
  51. 53.
    Farrar M.A. and Schreiber R.D., Annu Rev Immunol11, 571–611, 1993.Google Scholar
  52. 54.
    Upton C., Macen J.L., Schreiber M., and McFadden G., Virology184, 370–382, 1991.Google Scholar
  53. 55.
    Upton C., Mossman K., and McFadden G., Science258, 1369–1372, 1992.Google Scholar
  54. 56.
    Spriggs M.K., Hruby D.E., Maliszewski C.R., Pickup D.J., Sims J.E., Buller R.M.L., and VanSlyke J., Cell71, 145–152, 1992.Google Scholar
  55. 57.
    Alcami A. and Smith G.L., Cell71, 153–167, 1992.Google Scholar
  56. 58.
    Howard S.T., Chan Y.S., and Smith G.L., Virology180, 633–647, 1991.Google Scholar
  57. 59.
    Smith C. A., Farrah T., and Goodwin R.G., Cell76, 959–962, 1994.Google Scholar
  58. 60.
    Gershenwald J.E., Fong Y., Fahey T.J., Calvano S.E., Chizzonite R., Kilian P.L., Lowry S.F., and Moldawer L.L., Proc Natl. Acad Sci USA87, 4966–4970, 1990.Google Scholar
  59. 61.
    Wilson K.P., Black J-A.F., Thomson J.A., Kim E.E., Griffith J.P., Navia M.A., Murcko M.A., Chambers S.P., Aldape R.A., Raybuck S.A., and Livingston D.J., Nature370, 270–275, 1994.Google Scholar
  60. 62.
    Ray C.A., Black R.A., Kronheim S.R., Greenstreet T.A., Sleath P.R., Salvesen G.S., and Pickup D.J., Cell69, 597–604, 1992.Google Scholar
  61. 63.
    Kotwal G.J., Isaacs S.N., McKenzie R., Frank M.M., and Moss B., Science250, 827–830, 1990.Google Scholar
  62. 64.
    Kenneth B.M. and Day A.J., Immunology Today10, 177–180, 1989.Google Scholar
  63. 65.
    Isaacs S. N., Kotwal G. J., and Moss B., Proc Natl Acad Sci USA89, 628–632, 1992.Google Scholar
  64. 66.
    Engelstad M. and Smith G.L., Virology194, 627–637, 1993.Google Scholar
  65. 67.
    Martinez-Pomares L., Stern R. J., and Moyer R.W., J Virol67, 5450–5462, 1993.Google Scholar
  66. 68.
    Samuel C.E., Virology183, 1–11, 1991.Google Scholar
  67. 69.
    Whitaker-Dowling P. and Younger J.S., Virology131, 128–136, 1993.Google Scholar
  68. 70.
    Paez E. and Esteban M., Virology,134, 12–28, 1984.Google Scholar
  69. 71.
    Colby C. and Duesberg P.H., Nature222, 940–944, 1969.Google Scholar
  70. 72.
    Kaverin N.V., Varich N.L., Surgay V.V., and Chernos V.I., Virology65, 112–119, 1975.Google Scholar
  71. 73.
    Varich N.L., Sychova I.V., Kaverin N.V., Antonova T.P., and Chernos V.I., Virology96, 412–430, 1979.Google Scholar
  72. 74.
    Watson J.C., Chang H.-W., and Jacobs B., Virology185, 206–216, 1991.Google Scholar
  73. 75.
    Chang H.-W., Watson J. C., and Jacobs B.L., Proc Natl Acad Sci USA89, 4825–4829, 1992.Google Scholar
  74. 76.
    Davies M.V., Elroy-Stein O., Jagus R., Moss B., and Kaufman R.J., J Virol66, 1943–1950, 1992.Google Scholar
  75. 77.
    Davis M.V., Chang H.-W., Jacobs B.L., and Kaufman R.J., J. Virol67, 1688–1692, 1993.Google Scholar
  76. 78.
    Paez, E. and Esteban M., Virology134, 29–39, 1984.Google Scholar
  77. 79.
    Cohrs R.J., Condit R.C., Pacha R.F., Tompson C.L., and Sharma O.K., J Virol63, 948–951, 1989.Google Scholar
  78. 80.
    Pacha R.F., Meis R.J., and Condit R.C., J Virol64, 3853–3863, 1990.Google Scholar
  79. 81.
    Simpson D.A. and Condit R.C., J Virol68, 3642–3649, 1994.Google Scholar
  80. 82.
    Diaz-Guerra M. and Esteban M., J Virol67, 7561–7572, 1993.Google Scholar
  81. 83.
    Diaz-Guerra M., Kahn J.S., and Esteban M., Virology197, 485–491, 1993.Google Scholar
  82. 84.
    Moore J.B. and Smith G.L., EMBO J11, 1973–1980, 1992.Google Scholar
  83. 85.
    Upton C. and McFadden G., Virology152, 308–321, 1986.Google Scholar
  84. 86.
    Appella E., Weber I.T., and Blasi F., FEBS Lett231, 1–4, 1988.Google Scholar
  85. 87.
    Oie M., Shida H., and Ichihashi Y., Virology176, 494–504, 1990.Google Scholar
  86. 88.
    Upton C., Schiff L., Rice S.A., Dowdeswell T., Yang X., and McFadden G., J Virol68, 4186–4195, 1994.Google Scholar
  87. 89.
    Patel A.H., Gaffney D.F., Subak-Sharpe J.H., and Stow N.D., J Gen Virol71, 2013–2021, 1990.Google Scholar
  88. 90.
    Cooper J.A., Witter R., and Moss B., J Virol37, 284–294, 1981.Google Scholar
  89. 91.
    Cochran M.A., Puckett C., and Moss B., J Virol54, 30–37, 1985.Google Scholar
  90. 92.
    Kotwal G.J. and Moss B., J Virol63, 600–606, 1989.Google Scholar
  91. 93.
    Blomquist M.C., Hunt L.T., and Barker W.C., Proc Natl Acad Sci USA81, 7363–7367, 1984.Google Scholar
  92. 94.
    Stroobant P., Rice A.P., Gullick W.J., Cheng D.J., Kerr I.M., and Waterfield M.D., Cell42, 383–393, 1985.Google Scholar
  93. 95.
    Twardzik D.R., Brown J.P., Ranchalis J.E., Todaro G.J., and Moss B., Proc Natl Acad Sci USA82, 5300–5304, 1985.Google Scholar
  94. 96.
    Venkatesan S., Gershowitz A., and Moss B., J Virol44, 637–646, 1982.Google Scholar
  95. 97.
    Wittek R., Cooper J.A., and Moss B., J Virol39, 722–732, 1981.Google Scholar
  96. 98.
    Kotwal G.J. and Moss B., Virology167, 524–537, 1988.Google Scholar
  97. 99.
    Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M., Chichikov V.V., Gutorov V.V., Safronov P.F., Pozdnyakov S.G., Shelukhina E.M., Gashnikov P.V., Andzhaparidze O.G., and Sandakhchiev L.S., Doklady Akademii Nauk321, 402–406 1991 (in Russian).Google Scholar
  98. 100.
    Spehner D., Gillard S., Drillien R., and Kirn A., J Virol62, 1297–1304, 1988.Google Scholar
  99. 101.
    Perkus M.E., Goebel S.J., Davis S.W., Johnson G.P., Limbach K., Norton E.K., and Paoletti E., Virology179, 276–286, 1990.Google Scholar
  100. 102.
    Cooper J.A., Wittek R., and Moss B., J. Virol39, 733–745, 1981.Google Scholar
  101. 103.
    Kotwal G.J. and Moss B., Nature335, 176–178, 1988.Google Scholar
  102. 104.
    McKenzie R., Kotwal G.J., Moss B., Hammer C.H., and Frank M.M., J Infect Dis166, 1245–1250, 1992.Google Scholar
  103. 105.
    Belle Isle H., Venkatesan S., and Moss B., Virology112, 306–317, 1981.Google Scholar
  104. 106.
    Kotwal G.J., Hugin A.W., and Moss B., Virology171, 579–587, 1989.Google Scholar
  105. 107.
    Tamin A., Villarreal E.C., Weinrich S.L., and Hruby D.E., Virology165, 141–150, 1988.Google Scholar
  106. 108.
    Morgan J.R. and Roberts B.E., J Virol51, 283–297, 1994.Google Scholar
  107. 109.
    Gillard S., Spehner D., Drillien R., and Kirn A., Proc Natl Acad Sci USA83, 5573–5577, 1986.Google Scholar
  108. 110.
    Perkus M.E., Limbach K., and Paoletti E., J Virol63, 3829–3836, 1989.Google Scholar
  109. 111.
    Lux S.E., John K.M., and Bennett V., Nature344, 36–42, 1990.Google Scholar
  110. 112.
    Boursnell M.E.G., Foulds I.J., Campbell J.I., and Binns M.M., J Gen Virol69, 2995–3003, 1988.Google Scholar
  111. 113.
    Zhou J., Sun X.-Y., Fernando G.J.P., and Frazier I.H., Virology189, 678–686, 1992.Google Scholar
  112. 114.
    Law K.M. and Smith G.L., J Gen Virol73, 549–557, 1992.Google Scholar
  113. 115.
    Turner P.C. and Moyer R.W., J Virol66, 2076–2085, 1992.Google Scholar
  114. 116.
    Beattie E., Tartaglia J., and Paoletti E., Virology183, 419–422, 1991.Google Scholar
  115. 117.
    Slabaugh M.B. and Roseman N.A., Proc Natl Acad Sci USA86, 4152–4155, 1989.Google Scholar
  116. 118.
    McGeoch D.J., Nucleic Acids Res18, 4105–4110, 1990.Google Scholar
  117. 119.
    Broyles S.S., Virology195, 863–865, 1993.Google Scholar
  118. 120.
    Slabough M.B., Roseman N., Davis R., and Matthews C., J Virol62, 519–527, 1988.Google Scholar
  119. 121.
    Davis R.E. and Mathews C.K., Proc Natl Acad Sci USA90, 745–749, 1993.Google Scholar
  120. 122.
    Panicali D. and Paoletti E., Proc Natl Acad Sci USA79, 4927–4931, 1982.Google Scholar
  121. 123.
    Micryukov N.N., Chizhikov V.E., Prichodko G.G., Urmanov I.K., Serpinsky O.I., Blinov V.M., Nikulin A.E., and Vasilenko S.K., Biotechnology4, 442–449, 1988 (in Russian).Google Scholar
  122. 124.
    Perkus M.E., Panicalli D., Mercer S., and Paoletti E., Virology152, 285–297, 1986.Google Scholar
  123. 125.
    Golini F. and Kates J.R., J Virol49, 459–470, 1984.Google Scholar
  124. 126.
    Ogawa R., Calvert J.G., Yanagida N., and Nazerian K., J Gen Virol74, 55–64, 1993.Google Scholar
  125. 127.
    Hirt P., Hiller G., and Wittek R., J Virol58, 757–764, 1986.Google Scholar
  126. 128.
    Blasco R. and Moss B., J Virol65, 5910–5920, 1991.Google Scholar
  127. 129.
    Blasco R. and Moss B., J Virol66, 4170–4179, 1992.Google Scholar
  128. 130.
    Schmutz C., Payne L.G., Gubser J., and Wittek R., J Virol65, 3435–3442, 1991.Google Scholar
  129. 131.
    Payne L.G., Virology187, 251–260, 1992.Google Scholar
  130. 132.
    Wittek R., Hanggi M., and Hiller G., J Virol49, 371–378, 1994.Google Scholar
  131. 133.
    Bertholet C., Drillien R., and Wittek R., Proc Natl Acad Sci USA82, 2096–2100, 1985.Google Scholar
  132. 134.
    Kao S.-Y. and Bauer W.R., Virology159, 339–407, 1987.Google Scholar
  133. 135.
    Zhang Y. and Moss B., J Virol65, 6101–6110, 1991.Google Scholar
  134. 136.
    Gershon P.D., Ahn B.-Y., Garfield M., and Moss B., Cell66, 1269–1278, 1991.Google Scholar
  135. 137.
    Gershon P.D. and Moss B., Genes and Development6, 1575–1586, 1992.Google Scholar
  136. 138.
    Chang H.-W. and Jacobs B.L., Virology194, 537–547, 1993.Google Scholar
  137. 139.
    Jones E.V., Puckett C., and Moss B., J Virol61, 1765–1771, 1987.Google Scholar
  138. 140.
    Ahn B.-Y., Gershon P.D., Jones E.V., and Moss B., Mol Cell Biol10, 5433–5441, 1990.Google Scholar
  139. 141.
    Broyles S.S. and Pennington M.J., J Virol64, 5376–5382, 1990.Google Scholar
  140. 142.
    Rosales R., Harris N., and Ahn B.-Y., and Moss B., J Biol Chem269, 14260–14267, 1994.Google Scholar
  141. 143.
    Earl P.L., Jones E.V., and Moss B., Proc Natl Acad Sci USA83, 3659–3663, 1986.Google Scholar
  142. 144.
    Taddie J.A. and Traktman P., J Virol67, 4323–4336, 1993.Google Scholar
  143. 145.
    Loparev V.N., Bezdetnova O.N., and Chernos V.L., Molekulyarnaya Genetica, Mikrobiologiya i Virusologiya12, 33–38, 1988 (in Russian).Google Scholar
  144. 146.
    Traktman P., Sridhar P., Condid R.C., and Roberts B.E., J Virol49, 125–131, 1984.Google Scholar
  145. 147.
    Johnson G.P., Goebel S.J., Perkus M.E., Davis S.W., Winslow J.P., and Paoletti E., Virology181, 378–381, 1991.Google Scholar
  146. 148.
    Ahn B.-Y. and Moss B., Proc Natl Acad Sci USA89 7060–7064, 1992.Google Scholar
  147. 149.
    Ryazankina O.I., Muravlev A.I., Gutorov V.V., Mikrkukov N.N., Cheshenko I.O., and Shchelkunov S.N., Virus Res29 281–303, 1993.Google Scholar
  148. 150.
    Shchelkunov S.N., Ryazankina O.I., and Gashnikov P.V., Virus Res28 273–283, 1993.Google Scholar
  149. 151.
    Schmitt J.F.C. and Stunnenberg H.G., J Virol62 1889–1897, 1988.Google Scholar
  150. 152.
    Vos J.C. and Stunnenberg H.G., EMBO J7 3487–3492, 1988.Google Scholar
  151. 153.
    Hirschmann P., Vos J.C., and Stunnenberg H.G., J Virol64 6063–6069, 1990.Google Scholar
  152. 154.
    Tengelsen L.A., Slabaugh M.B., Bibler J.K., and Hruby D.E., Virology164 121–131, 1988.Google Scholar
  153. 155.
    Child S.J., Palumbo G.J., Buller R.M.L., and Hruby D.E., Virology174 625, 1990.Google Scholar
  154. 156.
    Takahashi T., Oie M., and Ichihashi Y., Virology202 844–852, 1994.Google Scholar
  155. 157.
    Kane E.M. and Shuman S., J Virol67 2689–2698, 1993.Google Scholar
  156. 158.
    Fathi Z. and Condit R.C., Virology181 258–272, 1991.Google Scholar
  157. 159.
    Fathi Z. and Condit R.C., Virology181 273–276, 1991.Google Scholar
  158. 160.
    Shuman S., Proc Natl Acad Sci USA89 10935–10939, 1992.Google Scholar
  159. 161.
    Meis R.J. and Condit R.C., Virology182 442–454, 1991.Google Scholar
  160. 162.
    Amegadzie B.Y., Ahn B.-Y., and Moss B., J Virol66 3003–3010, 1992.Google Scholar
  161. 163.
    Keck J.G., Baldick C.J., and Moss B., Cell61 801–809, 1990.Google Scholar
  162. 164.
    Wright C.F., Keck J.G., Tsai M.M., and Moss B., J Virol65 3715–3720, 1991.Google Scholar
  163. 165.
    Zhang Y., Keck J.G., and Moss B., J Virol66 6470–6479, 1992.Google Scholar
  164. 166.
    Franke C.A., Wilson E.M., and Hruby D.E., J Virol64 5988–5996, 1990.Google Scholar
  165. 167.
    Ravanello M.P. and Hruby D.E., J Gen Virol75 1479–1483, 1994.Google Scholar
  166. 168.
    Weir J.P. and Moss B., J Virol56 534–540, 1985.Google Scholar
  167. 169.
    Yang W.-P., Kao S.-Y., and Bauer W.R., Virology167 585–590, 1988.Google Scholar
  168. 170.
    Weir J.P. and Moss B., J Virol46 530–537, 1983.Google Scholar
  169. 171.
    Hruby D.E., Maki R.A., Miller D.B., and Ball L.A., Proc Natl Acad Sci USA80 3411–3415, 1983.Google Scholar
  170. 172.
    Gershon P.D. and Moss B., J Biol Chem268 2203–2210, 1993.Google Scholar
  171. 173.
    Broyles S.S. and Moss B., Proc Natl Acad Sci USA83 3141–3145, 1986.Google Scholar
  172. 174.
    Guan K., Broyles S.S., and Dixon J.E., Nature350 359–362, 1991.Google Scholar
  173. 175.
    Mahr A. and Roberts B.E., J Virol49 510–520, 1984.Google Scholar
  174. 176.
    Chertov O.Yu., Telezhinskaya I.N., Zaitseva E.V., Golubeva T.B., Zinovev V.V., Ovechkina L.G., Mazkova L.B., and Malygin E.G., Biomed Sci2 151–154, 1991.Google Scholar
  175. 177.
    Ahn B.-Y. and Moss B., Proc Natl Acad Sci USA89 3536–3540, 1992.Google Scholar
  176. 178.
    Kane E.M. and Shuman S., J Virol66 5752–5762, 1992.Google Scholar
  177. 179.
    Chikaev N.A., Muravlev A.I., Netesova N.A., and Malygin E.G., Molekulyarnaya Biologiya25 1533–1538, 1991 (in Russian).Google Scholar
  178. 180.
    Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S., Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gutorov V.V., Gashnikov P.V., Belanov E.F., Belavin P.A., Resenchuck S.M., Shelukhina E.M., Netesov S.V., Andzhaparidze O.G., and Sandakhchiev L.S., Mol Biol26 731–744, 1992.Google Scholar
  179. 181.
    Rosel J.L., Earl P.L., Weir J.P., and Moss B., J Virol60 436–449, 1986.Google Scholar
  180. 182.
    Shuman S. and Moss B., Proc Natl Acad Sci USA84 7478–7482, 1987.Google Scholar
  181. 183.
    Shaffer R. and Traktman P., J Biol Chem262 9309–9315, 1987.Google Scholar
  182. 184.
    Morgan J.R., Cohen L.K., and Roberts B.E., J Virol52 206–214, 1984.Google Scholar
  183. 185.
    Shuman S. and Morham S.G., J Biol Chem265 11967–11972, 1990.Google Scholar
  184. 186.
    Dyster L.M. and Niles E.G., Virology182 455–467, 1991.Google Scholar
  185. 187.
    Lee-Chen G.-J., Bourgeois N., Davidson K., Condit R.C., and Niles E.G., Virology163 64–79, 1988.Google Scholar
  186. 188.
    Stuart D.T., Upton C., Higman M.A., Niles E.G., and McFadden G., J Virol67 2503–2512, 1993.Google Scholar
  187. 189.
    Millns A.K., Carpenter M.S., and DeLange A.M., Virology198 504–513, 1994.Google Scholar
  188. 190.
    Upton C., Stuart D., and McFadden G., Proc Natl Acad Sci USA90 4518–4522, 1993.Google Scholar
  189. 191.
    Roseman N.A. and Hruby D.E., J Virol61 1398–1406, 1987.Google Scholar
  190. 192.
    Lee-Chen G.-J. and Niles E.G., Virology163 52–63, 1988.Google Scholar
  191. 193.
    Broyles S.S. and Fesler B.S., J Virol64 1523–1529, 1990.Google Scholar
  192. 194.
    Gershon P.D. and Moss B., Proc Natl Acad Sci USA87 4401–4405, 1990.Google Scholar
  193. 195.
    Li J. and Broyles S.S., J Biol Chem268 20016–20021 1993.Google Scholar
  194. 196.
    Quick S.D. and Broyles S.S., Virology178 603–605, 1990.Google Scholar
  195. 197.
    Ahn B.-Y., Jones E.V., and Moss B., J Virol64 3019–3024, 1990.Google Scholar
  196. 198.
    Maa J.-S., Rodriguez J.F., and Esteban M., J Biol Chem265 1569–1577, 1990.Google Scholar
  197. 199.
    Lai C., Gong S., and Esteban M., J Virol65 499–504, 1991.Google Scholar
  198. 200.
    Demkowicz W.E., Maa J.S., and Esteban M., J Virol66 368–398, 1992.Google Scholar
  199. 201.
    Rodriguez J.-R., Rodriguez D., and Esteban M., J Virol66 183–189, 1992.Google Scholar
  200. 202.
    Niles E.G. and Seto J., J Virol62 3772–3778, 1988.Google Scholar
  201. 203.
    Lee-Chen G.-J. and Niles E.G., Virology163 80–92, 1988.Google Scholar
  202. 204.
    Rodriguez J.F., Kahn J.S., and Esteban M., Proc Natl Acad Sci USA83 9566–9570, 1986.Google Scholar
  203. 205.
    Broyles S.S. and Moss B., J Virol61 1738–1742, 1987.Google Scholar
  204. 206.
    Niles E. G., Lee-Chen G.-J., Shuman S., Moss B., and Broyles S.S., Virology172 513–522, 1989.Google Scholar
  205. 207.
    Zhang Y. and Moss B., Virology187 643–653, 1992.Google Scholar
  206. 208.
    Keck J.G., Kovacs G.R., and Moss B., J Virol67 5740–5748, 1993.Google Scholar
  207. 209.
    Carpenter M.S. and DeLange A.M., Virology188 233–244, 1992.Google Scholar
  208. 210.
    Keck J.G., Fiegenbaum F., and Moss B., J Virol67 5749–5753, 1993.Google Scholar
  209. 211.
    Wittek R., Richner B., and Hiller G., Nucleic Acids Res12 4835–4848, 1984.Google Scholar
  210. 212.
    Rosel J.L. and Moss B., J Virol56 830–838, 1985.Google Scholar
  211. 213.
    Weinrich S.L. and Hruby D.E., Nucleic Acids Res14 3003–3016, 1986.Google Scholar
  212. 214.
    Ahn B.-Y., Rosel J., Cole N.B., and Moss B., J Virol66 971–982, 1992.Google Scholar
  213. 215.
    Van Meir E. and Wittek R., Arch Virol102 19–27, 1988.Google Scholar
  214. 216.
    Whitehead S.S. and Hruby D.E., Virology200 154–161, 1994.Google Scholar
  215. 217.
    Rodriguez D., Rodriguez J.F., and Esteban M., J Virol67 3435–3440, 1993.Google Scholar
  216. 218.
    Ichihashi Y., Takahashi T., and Oie M., Virology202 834–843, 1994.Google Scholar
  217. 219.
    Bayliss C.D. and Condit R.C., Virology194 254–262, 1993.Google Scholar
  218. 220.
    Hooda-Dhingra U., Patel D.D., Pickup D.J., and Condit R.C., Virology174 60–69, 1990.Google Scholar
  219. 221.
    Amegadzi B.Y., Holmes M.H., Cole N.B., Jones E.V., Earl P.L., and Moss B., Virology180 88–93, 1991.Google Scholar
  220. 222.
    Amegadzie B.Y., Sisler J.R., and Moss B., Virology186 777–782, 1992.Google Scholar
  221. 223.
    Rodriguez J.F. and Esteban M., J Virol61 3550–3554, 1987.Google Scholar
  222. 224.
    Rodriguez J.F. and Smith G.L., Nucleic Acids Res18 5347–5351, 1990.Google Scholar
  223. 225.
    Gong S., Lai S., and Esteban M., Virology178 81–91, 1990.Google Scholar
  224. 226.
    Amegadzie B.Y., Ahn B.-Y., and Moss B., J Biol Chem266 13712–13718, 1990.Google Scholar
  225. 227.
    Koonin E.V., Senkevich T.G., and Chernos V.I., Virus Genes7 89–94, 1993.Google Scholar
  226. 228.
    Duncan S.A. and Smith G.L., J Virol66 1610–1621, 1992.Google Scholar
  227. 229.
    Blasco R., Sisler J.R., and Moss B., J Virol67 3319–3325, 1993.Google Scholar
  228. 230.
    Blasco R., Cole N.B., and Moss B., J Virol65 4598–4608, 1991.Google Scholar
  229. 231.
    Duncan S.A. and Smith G.L., J Gen Virol73 1235–1242, 1992.Google Scholar
  230. 232.
    Smith G.L., de Carlos A., and Chan Y.S., Nucleic Acids Res17 7581–7590, 1989.Google Scholar
  231. 233.
    Hughes S.J., Johnston L.H., DeCarlos A., and Smith G.L., J Biol Chem266 20103–20109, 1991.Google Scholar
  232. 234.
    Smith G.L., Chan, Y.S., and Kerr S.M., Nucleic Acids Res17 9051–9062, 1989.Google Scholar
  233. 235.
    Kerr S.M. and Smith G.L., Nucleic Acids Res17 9039–9050, 1989.Google Scholar
  234. 236.
    Colinas R.J., Goebel S.J., Davis S.W., Johnson G.P., Norton E.K., and Paoletti E., Virology179 267–275, 1990.Google Scholar
  235. 237.
    Kerr S.M., Johnston L.H., Odell M., Duncan S.A., Law K.M., and Smith G.L., EMBO J10 4343–4350, 1991.Google Scholar
  236. 238.
    Shida H., virology150 451–462, 1986.Google Scholar
  237. 239.
    Jin D., Li Z., Jin Q., Yuwen H., and Hou Y., J Exp Med170 571–576, 1989.Google Scholar
  238. 240.
    Seki M., Oie M., Ichihashi Y., and Shida H., Virology175 372–384, 1990.Google Scholar
  239. 241.
    Brown C.K., Turner P.C., and Moyer R.W., J Virol65 3598–3606, 1991.Google Scholar
  240. 242.
    Traktman P., Anderson M.K., and Rempel R.E., J Biol Chem264 21458–21461, 1989.Google Scholar
  241. 243.
    Howard S.T. and Smith G.L., J Gen Virol70 3187–3201, 1989.Google Scholar
  242. 244.
    Lin S., Chen W., and Broyles S.S., J Virol66 2717–2723, 1992.Google Scholar
  243. 245.
    Banham A.H. and Smith G.L., Virology191 803–812, 1992.Google Scholar
  244. 246.
    Rempel R.E. and Traktman P., J Virol66 4413–4426, 1992.Google Scholar
  245. 247.
    Isaacs S.N., Wolffe E.J., Payne L.G., and Moss B., J Virol66 7217–7224, 1992.Google Scholar
  246. 248.
    Engelstad M., Howard S.T., and Smith G.L., Virology188 801–810, 1992.Google Scholar
  247. 249.
    Takahashi-Nishimaki F., Funahashi S.-I., Miki K., Hashizume S., and Sugimoto M., Virology181 158–164, 1991.Google Scholar
  248. 250.
    Wolffe E.J., Isaacs S.N., and Moss B., J Virol67 4732–4741, 1993.Google Scholar
  249. 251.
    Banham A.H. and Smith G.L., J Gen Virol74 2807–2812, 1993.Google Scholar
  250. 252.
    Pickup D.J., Ink B.S., Hu W., Ray C.A., and Joklik W.K., Proc Natl Acad Sci USA83 7698–7702, 1986.Google Scholar
  251. 253.
    Smith G.L., Howard S.T., and Chan Y.S., J Gen Virol70 2333–2343, 1989.Google Scholar
  252. 254.
    Palumbo G.J., Glasgow W.C., and Buller R.M.L., Proc Natl Acad Sci USA90 2020–2024, 1993.Google Scholar
  253. 255.
    Thompson J.P., Turner P.C., Ali A.N., Crenshaw B.C., and Moyer R.W., Virology197 328–338, 1993.Google Scholar
  254. 256.
    Smith G.L. and Chan Y.S., J Gen Virol72 511–518, 1991.Google Scholar
  255. 257.
    Ueda Y., Morikawa S., and Matsuura Y., Virology177 588–594, 1990.Google Scholar
  256. 258.
    Morikawa S. and Ueda Y., Virology193 753–761, 1993.Google Scholar
  257. 259.
    Perkus M.E., Goebel S., Davis S., Johnson G.P., Norton E., and Paoletti E., Virology180 406–410, 1991.Google Scholar
  258. 260.
    Buller R.M.L. and Palumbo G.J., in Binns M.M. and Smith G.L. (eds.).Recombinant Poxviruses. CRC Press, London, 1992, pp. 235–267.Google Scholar
  259. 261.
    Smith G.L. and Mackett M., in Binns M.M. and Smith G.L. (eds).Recombinant Poxviruses. CRC Press, London, 1992, pp. 81–122.Google Scholar

Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Sergei N. Shchelkunov
    • 1
  1. 1.Institute of Molecular BiologyState Research Center of Virology and Biotechnology “Vector”Koltsovo, Novosibirsk regionRussia

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