Virus Genes

, Volume 10, Issue 1, pp 53–71 | Cite as

Functional organization of variola major and vaccinia virus genomes

  • Sergei N. Shchelkunov


Comparison of the genomic organization of variola and vaccinia viruses has been carried out. Molecular factors of virulence of these viruses is the focus of this review. Possible roles of the genes of soluble cytokine receptors, complement control proteins, factors of virus replication, and dissemination in vivo for variola virus pathogenesis are discussed. The existence of “buffer” genes in the vaccinia virus genome is proposed.

Key words

smallpox orthopoxvirus variola virus vaccinia virus molecular factors of virulence 


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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Sergei N. Shchelkunov
    • 1
  1. 1.Institute of Molecular BiologyState Research Center of Virology and Biotechnology “Vector”Koltsovo, Novosibirsk regionRussia

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