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Zinc and copper levels in plasma, erythrocytes, and whole blood in cancer patients

Zink- und Kupferspiegel in Plasma, Erythrozyten und Vollblut bei Karzinompatienten

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Zinc and copper levels in erythrocytes, plasma, and whole blood were determined in 35 cancer patients and compared with 24 normal individuals. A decrease in zinc was found in all three blood constituents of the cancer patients. The decrease was significant in plasma and whole blood and nonsignificant in erythrocytes. Copper levels in the cancer group showed a slight and nonsignificant increase in erythrocytes, plasma, and whole blood. The copper to zinc ratio revealed a significant increase only for plasma levels. Further investigations are indicated to determine whether these two elements could serve as indicators for diagnosis or prognosis in cancer patients.


Zink- und Kupferspiegel in Erythrozyten, Plasma, und Vollblut wurden bei 35 Karzinompatienten bestimmt, und vergleichsweise bei 24 Normalpersonen. Ein Abfall von Zink wurde bei Karzinompatienten in allen drei untersuchten Blutbestandteilen gefunden. Dieser Abfall war im Plasma und Vollblut signifikant und in Erythrozyten nicht-signifikant. Der Kupferspiegel zeigte in der Karzinomgruppe einen leichten und nicht-signifikanten Anstieg in Erythrozyten, Plasma, und Vollblut. Der Kupfer/Zink-Quotient ergab einen signifikanten Anstieg nur für den Plasmaspiegel. Weitere Untersuchungen erscheinen angezeigt um festzustellen, ob die beiden Elemente als Indikatoren für Diagnose und Prognose bei Karzinompatienten dienen können.

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Correspondence to Y. Aldor MD.

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Aldor, Y., Walach, N., Modai, D. et al. Zinc and copper levels in plasma, erythrocytes, and whole blood in cancer patients. Klin Wochenschr 60, 375–377 (1982). https://doi.org/10.1007/BF01721629

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Key words

  • Cancer
  • Zinc
  • Copper


  • Karzinom
  • Zink
  • Kupfer