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Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid


A non-peptide library of 2001 compounds has been prepared utilizing solid-phase techniques. The split/combine method was demonstrated to work well to form mixtures of compounds based on 3-amino-5-hydroxybenzoic acid as a core structure. The benzoic acid of the core structure served as the attachment point for the resin and the amino and hydroxy positions were variably substituted.

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Correspondence to Sharon M. Dankwardt.

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Dankwardt, S.M., Phan, T.M. & Krstenansky, J.L. Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid. Mol Divers 1, 113–120 (1996).

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  • Solid-phase synthesis
  • Combinatorial approach
  • Non-peptide library
  • 3-Amino-5-hydroxybenzoic acid