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Inappropriate secretion of antidiuretic hormone, polydipsia and hypothalamic calcifications

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Summary

We studied a 41 year old patient who had pathologic fluid intake of 10l/day together with syndrome of inappropriate antidiuretic hormone. Imaging studies revealed a lesion of the anterior wall of the third cerebral ventricle. A review of relevant literature indicated several different disturbances by which alterations of thirst, vasopressin-secretion and abnormalities of anterior third ventricle may be associated. The present case presents an unusual and potentially dangerous combination in this spectrum of changes.

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Abbreviations

PRA:

plasma renin activity

TSH:

thyroid stimulating hormone

PGE2 :

prostaglandin E2

ADH:

antidiuretic hormone

SIADH:

syndrome of inappropriate antidiuretic hormone secretion

References

  1. 1.

    Bartter FC, Schwartz WB (1967) The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:790–806

  2. 2.

    Baylis PH, Gaskill MB, Robertson GL (1981) Vasopressin secretion in primary polydipsia and cranial diabetes insipidus. Quarterly J Med 199:345–358

  3. 3.

    Beck LH (1979) Hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone. New Engl J Med 301:528–530

  4. 4.

    Bichet D, Lum G, Handelman W, Schrier R (1981) Basal ganglia calcification and symptomatic hypernatremia associated with the syndrome of inappropriate antidiuretic hormone secretion. Kidney Int 19:119 (abstract)

  5. 5.

    Cooke RE (1972) Thirst mechanism disturbance. Clin Pediatrics 11:552

  6. 6.

    De Rubertis FR, Michelis MF, Davis BB (1974) “Essential” hypernatremia. Arch Int Med 134:889–894

  7. 7.

    Gross PA, Kim JK, Anderson RJ (1983) Mechanism of escape from desmopressin in the rat. Circ Res 53:794–804

  8. 8.

    Haber E, Koerner T, Page LB, Kleman B, Purnode A (1969) Application of a RIA for angiotensin I to the physiologic measurement of PRA in normal subjects. J Clin Endocrinol Metab 29:1349–1355

  9. 9.

    Hensen J, Bähr V, Oelkers W (1988) Schwere Hypernatriämie bei erworbener Störung der Durst- und Vasopressin-Regulation. Klin Wochenschr 66:498–501

  10. 10.

    Jaenike JR, Waterhouse C (1961) The renal response to sustained administration of vasopressin and water in man. J Clin Endocrinol Metab 21:231–242

  11. 11.

    Mahoney JH, Goodman AD (1968) Hypernatremia due to hypodipsia and elevated threshold for vasopressin release. New Engl J Med 279:1191–1196

  12. 12.

    Martinez-Maldonado M (1980) Inappropriate antidiuretic hormone secretion of unknown origin. Kidney Int 17:554–567

  13. 13.

    Rascher W, Lang RE, Unger T, Ganten D, Gross F (1982) Vasopressin in brain of spontaneously hypertensive rats. Am J Physiol 242:H496-H499

  14. 14.

    Schlaff-Blass E, Robertson GL, Rosenfield RL (1983) Chronic hypernatremia from a congenital defect in osmoregulation of thirst and vasopressin. J Pediatr 102:703–708

  15. 15.

    Schrier RW (1985) Treatment of hyponatremia. N Engl J Med 312:1121–1122

  16. 16.

    Vecsei P, Gless KH (1975) Aldosterone radioimmunoassay. In: Vecsei P (ed) Aldosterone radioimmunoassay. Enke, Stuttgart

  17. 17.

    Whitaker MD McArthur RG, Corenblum B, Davidman M, Haslam RM (1979) Idiopathic, sustained, inappropriate secretion of ADH with associated hypertension and thirst. Am J Med 67:511–515

  18. 18.

    Zimmerman EA, Ma Ly, Nilaver G (1987) Anatomical basis of thirst and vasopressin secretion. Kidney Int 32 (Suppl 21):S14-S19

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Gross, P., Wichmann, A., Walb, D. et al. Inappropriate secretion of antidiuretic hormone, polydipsia and hypothalamic calcifications. Klin Wochenschr 67, 730–733 (1989). https://doi.org/10.1007/BF01721292

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Key words

  • Vasopressin
  • Thirst