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Inappropriate secretion of antidiuretic hormone, polydipsia and hypothalamic calcifications

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We studied a 41 year old patient who had pathologic fluid intake of 10l/day together with syndrome of inappropriate antidiuretic hormone. Imaging studies revealed a lesion of the anterior wall of the third cerebral ventricle. A review of relevant literature indicated several different disturbances by which alterations of thirst, vasopressin-secretion and abnormalities of anterior third ventricle may be associated. The present case presents an unusual and potentially dangerous combination in this spectrum of changes.

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plasma renin activity


thyroid stimulating hormone

PGE2 :

prostaglandin E2


antidiuretic hormone


syndrome of inappropriate antidiuretic hormone secretion


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Gross, P., Wichmann, A., Walb, D. et al. Inappropriate secretion of antidiuretic hormone, polydipsia and hypothalamic calcifications. Klin Wochenschr 67, 730–733 (1989). https://doi.org/10.1007/BF01721292

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Key words

  • Vasopressin
  • Thirst