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Fosfomycin protects against tubulotoxicity induced byCis-diaminedichloroplatin and cyclosporin A in the rat

Summary

The nephroprotective effect of fosfomycin against tubulotoxicity induced bycis-diaminedichloroplatin (DDP) and cyclosporin A (Cs) was studied in the rat. The parameter of nephrotoxicity was urinary tubular cell excretion. The experiments revealed that fosfomycin, given either concomitantly or in advance was able to reduce the nephrotoxic effect of DDP and Cs significantly. We conclude from these studies that fosfomycin is a broad-spectrum nephroprotective agent.

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Abbreviations

Cs:

cyclosporin A

DDP:

cis-diaminedichloroplatin

HPLC:

high performance liquid chromatography

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Sack, K., Schulz, E., Marre, R. et al. Fosfomycin protects against tubulotoxicity induced byCis-diaminedichloroplatin and cyclosporin A in the rat. Klin Wochenschr 65, 525–527 (1987). https://doi.org/10.1007/BF01721040

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Key words

  • Fosfomycin
  • Tubulotoxicity
  • Nephroprotection
  • Cyclosporin A
  • Cis-Diaminedichloroplatin