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, Volume 60, Issue 1, pp 37–40 | Cite as

Recombinant interferon-alpha, but not interferon-gamma is effective therapie for essential thrombocythemia

  • M. J. B. P. Abegg-Werter
  • J. M. M. Raemaekers
  • B. E. de Pauw
  • C. Haanen
Original article

Summary

Recombinant interferon-gamma with a starting dose of 0.5 mg 3×/week subcutaneously, was administered to 6 patients with essential thrombocythemia (median platelet count 1172×109/1, range 602–1564). Four of the patients had received alkylating agents previously. Hematological remission, defined as a decrease in platelet counts to ≤ 350×109/l, was observed in none of these patients. Subsequently 4 of these 6 patients, supplemented by 2 others were treated with interferonalpha2c at a dose of 5×106 U daily subcutaneously. Five patients showed hematological remission. In case of hematological remission the interferonalpha dosis was reduced to 5× an thereafter to 3× weekly 5×106 U. During an observation period ranging from 12–41 weeks platelet counts remained normal in all patients. Side-effects were mild and consisted of fever, myalgias, malaise and itching occurring mainly during the first month of treatment. No dose adaptation was required. The patients treated previously with interferon-gamma experienced the side effects from this drug less tolerably than those from the alpha-compound. These observations suggest that recombinant interferonalpha may be an effective drug in treating essential thrombocythemia resulting in a sustained response.

Key words

Thrombocythemia Interferon-alpha Interferon-gamma 

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References

  1. 1.
    Bellucci S, Harousseau JL, Brice P, Tobelem G (1988) Treatment of essential thrombocythaemia by alpha 2a interferon. Lancet II: 960–961Google Scholar
  2. 2.
    Case DC Jr (1984) Therapy of essential thrombocythemia with thiotepa and chlorambucil. Blood 63: 51–54Google Scholar
  3. 3.
    Giles FJ, Gray AG, Brozovic M, Grant IR, Machin SJ, Richards JDM, Venutas S, Singer CRJ, Young KL, Davies SC, Hoffbrand AV, Mehta AB, Thomas MJG, Goldstone AH (1988) Alpha-interferon therapy for essential thrombocythaemia. Lancet II: 70–72Google Scholar
  4. 4.
    Gisslinger H, Linkesch W, Fritz E, Ludwig H, Chott A, Radaszkiewicz Th (1989) Long-term interferon therapy for thrombocytosis in myeloproliferative diseases. Lancet I: 634–637Google Scholar
  5. 5.
    Gugliotta L, Bagnara GP, Catani L, Gaggioli L, Guarini A, Zauli G, Belmonte MM, Lauria F, Macchi S, Tura S (1989) In vivo and in vitro inhibitory effect of α-interferon on megakaryocyte colony growth in essential thrombocythaemia. Br J Haematol 71: 177–181Google Scholar
  6. 6.
    Jabaily J, Iland HJ, Laszlo J, Massey EW, Faguet GB, Brière J, Landaw SA, Pisciotta AV (1983) Neurologic manifestations of essential thrombocythemia. Ann Int Med 99: 513–518Google Scholar
  7. 7.
    Krim M (1980) Towards tumor therapy with interferons, Part I. Interferons: production and properties. Blood 55: 711–721Google Scholar
  8. 8.
    Kurzrock R, Quesada JR, Talpaz M, Hersh EM, Reuben JM, Sherwin SA, Gutterman JU (1986) Phase I study of multiple dose intramuscularly administered recombinant gamma interferon. J Clin Oncol 4: 1101–1109Google Scholar
  9. 9.
    Ludwig H, Linkesch W, Gisslinger H, Fritz E, Sinzinger H, Radaszkiewicz T, Chott A, Flener R, Micksche M (1987) Interferon-alpha corrects thrombocytosis in patients with myeloproliferative disorders. Cancer Immunol Immunother 25: 266–273Google Scholar
  10. 10.
    May D, Wandl UB, Niederle N (1989) Treatment of essential thrombocythaemia with interferon alpha-2b. Lancet I: 96Google Scholar
  11. 11.
    Michiels JJ, Kate FWJ ten, Vuzevski VD, Abels J (1984) Histopathology of erythromelalgia in thrombocythaemia. Histopathology 8: 669–678Google Scholar
  12. 12.
    Murphy S, Iland H, Rosenthal D, Laszlo J (1986) Essential thrombocythemia: an interim report from the polycythemia vera study group. Semin Hematol 23: 177–182Google Scholar
  13. 13.
    Pauw BE de, Bergen ANL van, Haanen C, Steenbergen J (1985) Intermittent melphalan in the treatment of essential thrombocytosis with haemorrhage or thrombosis. Scand J Haematol 35: 448–450Google Scholar
  14. 14.
    Pette JEW van de, Prochazka AV, Pearson TC, Singh AK, Dickson ER, Wetherley-Mein G (1986) Primary thrombocythaemia treated with busulphan. Br J Haematol 61: 229–237Google Scholar
  15. 15.
    Preston FE (1982) Essential thrombocythaemia. Lancet I: 1021Google Scholar
  16. 16.
    Rigby WFC, Ball ED, Guyre PM, Fanger MW (1985) The effects of recombinant-DNA-derived interferons on the growth of myeloid progenitor cells. Blood 65: 858–861Google Scholar
  17. 17.
    Schafer AI (1984) Bleeding and thrombosis in the myeloproliferative disorders. Blood 64: 1–12Google Scholar
  18. 18.
    Sogtman HD, Matthay RA, Putman CE (1977) Cytotoxic drug induced lung disease. Am J Med 62: 608–615Google Scholar
  19. 19.
    Talpaz M, Mavligit G, Keating M, Walters RS, Gutterman JU (1983) Human leukocyte interferon to control thrombocytosis in chronic myelogenous leukemia. Ann Int Med 99: 789–792Google Scholar
  20. 20.
    Talpaz M, Kantarjian HM, McCredie K, Trujillo JM, Keating MJ, Gutterman JU (1986) Hematologic remission and cytogenetic improvement induced by recombinant human interferon alphaA in chronic myelogenous leukemia. N Engl J Med 314: 1065–1069Google Scholar
  21. 21.
    Toh BT, Gregory SA, Knopse WH (1988) Acute leukemia following treatment of polycythemia vera and essential thrombocythemia with uracil mustard. Am J Hematol 28: 58–60Google Scholar
  22. 22.
    Toy JL (1983) The interferons. Clin Exp Immunol 54: 1–13Google Scholar
  23. 23.
    Velu T, Delwiche F, Gangji D, Monsieur R, Flament J, Stryckmans P, Wybran J, Bellens R (1985) Therapeutic effect of human recombinant interferon-alpha-2 C in essential thrombocythaemia. Oncology 42 [Suppl 1]: 10–14Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. J. B. P. Abegg-Werter
    • 1
  • J. M. M. Raemaekers
    • 1
  • B. E. de Pauw
    • 1
  • C. Haanen
    • 1
  1. 1.Division of Hematology, Department of MedicineUniversity Hospital NijmegenNijmegenThe Netherlands

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