, Volume 33, Issue 3, pp 157–162 | Cite as

The genetic basis of negative selection of Tcrb-Vll+ T cells

  • Kyuhei Tomonari
  • Sue Fairchild
Original articles


Non-H-2 genes responsible for negative selection of Tcrb-V 11+ T cells were examined using backcross mice of various strains with C58, which does not delete Tcrb-V 11+ T cells. Two independently segregating genes were found: one leading to partial deletion was closely linked toLy-2/Ly-3 on chromosome 6, and the second giving virtually complete deletion has not yet been mapped. The A strain had only the former, whereas BALB/c, BALBK, B10.BR, CBA-T6, C3H/He, and DBA/2 expressed both of these genes. Although a gene(s) of the NIH strain led only to partial deletion, the chromosomal localization of the gene(s) has not yet been determined: no informative polymorphic molecules are expressed from genes on chromosome 6 of this strain.


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Kyuhei Tomonari
    • 1
  • Sue Fairchild
    • 1
  1. 1.Transplantation Biology SectionMRC Clinical Research CentreHarrowEngland

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