Klinische Wochenschrift

, Volume 60, Issue 17, pp 954–957

Functional heterogeneity of mast cells from different species and tissues

  • F. L. Pearce
2. Mechanisms Of Adverse Reactions And Histamine Release In Anaesthesia And Surgery

Summary

The systemic responses of different animals to a number of histamine liberators and the effects of these compounds on isolated tissue mast cells in vitro are examined. Mast cells from different species and even from individual tissues within a single animal are shown to vary markedly in their response to given inducers. On this basis, the usefulness of animal models in predicting whether a particular compound may act as a histamine liberator in man is discussed.

Key words

Histamine Histamine liberators Mast cells Mast cell heterogeneity 

Funktionelle Ungleichartigkeit der Mastzellen von verschiedenen Spezies

Zusammenfassung

Die körperlichen Reaktionen von verschiedenen Tieren auf mehrere Histaminliberatoren und die Wirkungen von diesen Substanzen an isolierten Gewebemastzellen in vitro sind untersucht worden. Mastzellen von verschiedenen Spezies und selbst von individuellen Geweben innerhalb eines einzelnen Tieres sind sehr unterschiedlich in ihrer Reaktion auf gegebene Liberatoren. Auf dieser Grundlage wird die Nützlichkeit in der Voraussage ob ein bestimmtes Mittel als Histaminliberator im Menschen wirken kann diskutiert.

Schlüsselwörter

Histamin Histaminliberatoren Mastzellen Mastzellungleichartigkeit 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • F. L. Pearce
    • 1
  1. 1.Department of ChemistryUniversity College LondonLondonUK

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