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Parvovirus B19 infection in HIV-1 infected patients with anemia

Parvovirus B19 Infektion bei HIV-infizierten Patienten mit Anämie

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Summary

Serum samples were analysed for IgM and IgG antibodies to parvovirus by ELISA and for parvovirus B19 DNA by polymerase chain reaction (PCR) in 69 HIV-1 infected Swedish patients with anemia and in 37 HIV-1 infected subjects without anemia. In 5/69 anemic patients, parvovirus B19 DNA was detected despite the lack of IgM antibody activity to the virus. The detection of parvovirus B19 DNA was significantly correlated to the degree of anemia in the anemic patients. In two patients who had a chronic anemia, a persistent parvovirus infection was detected by PCR, but not by serology, for 1 and 1.5 years, respectively. The results suggest that persistent parvovirus infection is a rare cause of anemia, but important to identify, since the infection is potentially treatable with intravenous immunoglobulin.

Zusammenfassung

Serumproben von 69 HIV-infizierten schwedischen Patienten mit Anämie und von 37 HIV-Infizierten ohne Anämie wurden mittels ELISA auf IgM- und IgG-Antikörper gegen Parvovirus B19 untersucht, auch wurde mittels Polymerasekettenreaktion (PCR) das Vorliegen von Parvovirus B19 DNA geprüft. Bei 5/69 anämischen Patienten war Parvovirus B19 DNA nachzuweisen, obwohl keine IgM-Antikörperreaktion gegen das Virus vorlag. Zwischen dem Nachweis von Parvovirus B19 DNA und dem Schweregrad der Anämie bestand bei den anämischen Patienten eine signifikante Korrelation. Bei zwei Patienten mit seit 1 beziehungsweise 1 1/2 Jahren bestehender chronischer Anämie konnte unter Anwendung der PCR eine persistierende Parvovirus-Infektion festgestellt werden, für die serologisch kein Hinweis vorlag. Die Ergebnisse lassen annehmen, daß die persistierende Parvovirus-Infektion eine seltene Ursache für eine Anämie darstellt, ihr Nachweis jedoch wegen der möglichen Behandlung mit intravenösem Immunglobulin von klinischer Relevanz ist.

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Correspondence to Dr. Christina Jorup-Rönström M. D., Ph. D..

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Gyllensten, K., Jorup-Rönström, C., Halvarsson, M. et al. Parvovirus B19 infection in HIV-1 infected patients with anemia. Infection 22, 356–358 (1994). https://doi.org/10.1007/BF01715548

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Keywords

  • Polymerase Chain Reaction
  • Anemia
  • Infected Patient
  • Intravenous Immunoglobulin
  • Anemic Patient