Infection

, Volume 22, Issue 6, pp 407–410 | Cite as

The role of hepatitis E virus in acute sporadic non-A, non-B hepatitis

  • I. Köksal
  • K. Aydin
  • B. Kardes
  • H. Turgut
  • F. Murt
Originalia

Summary

Hepatitis E virus (HEV) is the cause of enterically transmitted non-A, non-B (NANB) hepatitis. Water-borne epidemics have been reported in many developing countries primarily affecting young and middle-aged adults. To determine the role of HEV in acute sporadic NANB hepatitis, we have studied the profiles of anti-HEV IgG in the sera of patients previously diagnosed for NANB hepatitis. We tested the sera of 53 patients with acute NANB hepatitis and 100 healthy people as a control group for anti-HEV IgG. Thirty-nine of the 53 patients (73.3%) and none of the control group were positive for HEV infection, according to results shown by ELISA. This result suggests that HEV is a common cause of acute sporadic NANB hepatitis in Turkey. Further studies are needed in the other regions to determine the true prevalence of HEV infection in Turkey.

Die Bedeutung des Hepatitis E-Virus bei akuter Non-A, Non-B Hepatitis

Zusammenfassung

Das Hepatitis E Virus (HEV) ist der Erreger der enteral übertragenen Non-A, Non-B (NANB)-Hepatitis. Epidemien durch verseuchtes Wasser wurden aus vielen Entwicklungsländern berichtet, sie betrafen vor allem Jugendliche und Erwachsene mittleren Alters. Um die Rolle des HEV bei der akuten NANB-Hepatitis zu bestimmen, haben wir die anti-HEV IgG Profile der Seren in früher als NANB-Hepatitis diagnostizierten Fällen bestimmt. Wir testeten die Seren von 53 Patienten mit akuter NANB-Hepatitis und von 100 gesunden Kontrollpersonen auf anti-HEV IgG. Eine HEV-Infektion wurde nach den Ergebnissen des ELISA bei 39 der 53 Patienten (73,3%), aber bei keiner Person der Kontrollgruppe festgestellt. Die Ergebnisse lassen annehmen, daß HEV eine häufige Ursache der sporadischen NANB-Hepatitis in der Türkei ist. Weitere Studien in anderen Regionen sind erforderlich, um die wirkliche Prävalenz der HEV-Infektion in der Türkei zu bestimmen.

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References

  1. 1.
    Bradley, D. W. Hepatitis E: epidemiology, aetiology and molecular biology. Rev. Med. Virol. 2 (1992) 19–28.Google Scholar
  2. 2.
    Chauhan, A., Jameel, S., Dilawari, J. B., Chawla, Y. K., Kaur, U., Ganguly, N. K. Hepatitis E virus transmission to a volunteer. Lancet 341 (1993) 149–150.Google Scholar
  3. 3.
    Asher, L. V. S., Innis, B. L., Shrestha, M. P., Ticehurst, J., Baze, W. B. Virus-like particles in the liver of a patient with fulminant hepatitis and antibody to hepatitis E virus. J. Med. Virol. 31 (1990) 229–233.Google Scholar
  4. 4.
    Lok, A. S. F., Kwan, W. K., Moeckli, R., Yarbough, P. O., Chan, R. T., Reyes, G. R., Lai, C-L., Chung, H-T., Lai, T. S. T. Seroepidemiological survey of hepatitis E in Hong Kong by recombinant-based enzyme immunoassays. Lancet 340 (1992) 1205–1208.Google Scholar
  5. 5.
    Krawczynski, K. Hepatitis E. Hepatology 17 (1993) 932–941.Google Scholar
  6. 6.
    Coursaget, P., Krawczynski, K., Buisson, Y., Nizov, C., Molinié, C. Hepatitis E and hepatitis C virus infections among French soldiers with non-A, non-B hepatitis. J. Med. Virol. 39 (1993) 163–166.Google Scholar
  7. 7.
    Bradley, D. W. Enterically-transmitted non-A, non-B hepatitis. Br. Med. Bull. 46 (1990) 442–461.Google Scholar
  8. 8.
    Zuckerman, A. J. Hepatitis E virus: the main cause of enterically transmitted non-A, non-B hepatitis. Br. Med. J. 300 (1990) 1475–1476.Google Scholar
  9. 9.
    Moaven, L. D., Fuller, A. J., Doultree, J. C., Marshall, J. A., Bowden, D. S., Moeckli, R. A., Locarnini, S. A. A case of acute hepatitis E in Victoria. Med. J. Aust. 159 (1993) 124–125.Google Scholar
  10. 10.
    Huang, C-C., Nguyen, D., Fernandez, J., Yun, K. Y., Fry, K. E., Bradley, D. W., Tam, A. W., Reyes, G. R. Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV). Virology 191 (1992) 550–558.Google Scholar
  11. 11.
    Belabbes, E. H., Bouguermouth, A., Benatullah, A., Illoul, G. Epidemic non-A, non-B hepatitis in Algeria: strong evidence for its spreading by water. J. Med. Virol. 16 (1985) 257–263.Google Scholar
  12. 12.
    Ticehurst, J., Popkin, T. J., Bryan, J. P., Innis, B. L., Duncan, J. F., Ahmed, A., Iqbal, M., Malik, I., Kapikian, A. Z., Legters, L. J., Purcell, R. H. Association of hepatitis E virus with an outbreak of hepatitis in Pakistan: serologic responses and pattern of virus excretion. J. Med. Virol. 36 (1992) 84–92.Google Scholar
  13. 13.
    Tandon, B. N., Joshi, Y. K., Jain, S. K., Gandhi, B. M., Mathiesen, L. R., Tandon, H. D. An epidemic of non-A, non-B hepatitis in north India. Ind. J. Med. Res. 75 (1982) 739–744.Google Scholar
  14. 14.
    Kane, M. A., Bradley, D. W., Shrestha, S. M., Maynard, J. E., Cook, E. H., Mishra, P. P., Joshi, D. D. Epidemic non-A, non-B hepatitis in Nepal: recovery of possible etiologic agent and transmission studies in marmosets. JAMA 252 (1984) 3140–3145.Google Scholar
  15. 15.
    Myint, H., Soe, M. M., Khin, T., Myint, T. M., Tin, K. M. A clinical and epidemiological study of an epidemic of non-A, non-B hepatitis in Rangoon. Am. J. Trop. Med. Hyg. 34 (1985) 1183–1189.Google Scholar
  16. 16.
    Goldsmith, R. J., Yarbough, P. O., Reyes, G. R., Fry, K. E., Gabor, K. A., Kamel, M., Zakaria, S., Amer, S., Gaffar, Y. Enzyme-linked immunosorbent assay for diagnosis of acute sporadic hepatitis E in Egyptian children. Lancet 339 (1992) 328–331.Google Scholar
  17. 17.
    Hyams, K. C., Purdy, M. A., Kaur, M., Mc Carthy, M. C., Hussain, M. A. M., El-Tigani, A., Krawczynski, K., Bradley, D. W., Carl, M. Acute sporadic hepatitis E in Sudanese children: analysis based on a new western blot assay. J. Infect. Dis. 165 (1992) 1001–1005.Google Scholar
  18. 18.
    Tsega, E., Krawczynski, K., Hansson, B. G., Nordenfelt, E., Negusse, Y., Alemu, W., Bahru, Y. Outbreak of acute hepatitis E virus infection among military personnel in Northern Ethiopia. J. Med. Virol. 34 (1991) 232–236.Google Scholar
  19. 19.
    Velázquez, O., Stetler, H. C., Avila, C., Ornelas, G., Alvarez, C., Hadler, S. C., Bradley, D. W., Sepúlveda, J. Epidemic transmission of enterically transmitted non-A, non-B hepatitis in Mexico, 1986–1987. JAMA 263 (1990) 3281–3285.Google Scholar
  20. 20.
    Dawson, G. J., Mushahwar, I. K., Chau, K. H., Gitnick, G. L. Detection of long-lasting antibody to hepatitis E virus in a US traveller to Pakistan. Lancet 340 (1992) 426–427.Google Scholar
  21. 21.
    Public Health Service, Centers for Disease Control Hepatitis E among U. S. travelers, 1989–1992. MMWR 42 (1993) 1–4.Google Scholar
  22. 22.
    Bader, T. F., Krawczynski, K., Polish, L. B., Favorov, M. O. Hepatitis E in a U. S. traveler to Mexico. N. Engl. J. Med. 325 (1991) 1659.Google Scholar
  23. 23.
    De Cock, K. M., Bradley, D. W., Sandford, N. L., Govinarojen, S., Maynard, J. E., Redeker, A. G. Epidemic non-A, non-B hepatitis in patients from Pakistan. Ann. Intern. Med. 106 (1987) 227–230.Google Scholar
  24. 24.
    Skidmore, S. J., Yarbough, P. O., Galbor, K. A., Tam, A. W., Reyes, G. R. Imported hepatitis E in UK. Lancet 337 (1991) 1541.Google Scholar
  25. 25.
    Tsega, E., Hansson, B. G., Krawczynski, K., Nordenfelt, E. Acute sporadic viral hepatitis in Ethiopia: causes, risk factors and effects on pregnancy. Clin. Infect. Dis. 14 (1992) 961–965.Google Scholar
  26. 26.
    Khuroo, M. S., Tell, M. R., Skidmore, S. J., Sofi, M. A., Khuroo, M. I. Incidence and severity of viral hepatitis in pregnancy. Am. J. Med. 70 (1981) 252–255.Google Scholar
  27. 27.
    Tam, A. W., Smith, M. M., Guerra, M. E., Huang, C. C., Bradley, D. W., Fry, K. E., Reyes, G. R. Hepatitis E virus (HEV): molecular cloning and sequencing of the full length viral genome. Virology 185 (1991) 120–131.Google Scholar
  28. 28.
    Yarbough, P. O., Tam, A. W., Fry, K. E., Krawczynski, K., Mc Caustland, K. A., Bradley, D. W., Reyes, G. R. Hepatitis E virus: identification of type-common epitopes. J. Virol. 65 (1991) 5790–5797.Google Scholar
  29. 29.
    Favorov, M. O., Fields, H. A., Purdy, M. A., Yashina, T. L., Aleksandrov, A. G., Alter, M. J., Yarasheva, D. M., Bradley, D. W., Margolis, H. S. Serologic identification of hepatitis E virus infections in epidemic and endemic settings. J. Med. Virol. 36 (1992) 246–250.Google Scholar
  30. 30.
    Baki, A., Aynaci, M., Köksal, I. Prevalence of antibody to hepatitis A virus among children in Trabzon, Turkey. Infection 21 (1993) 132–133.Google Scholar
  31. 31.
    Turfan, M., Arikan, E. The prevalence of anti-HAV IgG in various groups. J. Klimik 2 (1989) 182–184.Google Scholar
  32. 32.
    Zaaijer, H. L., Kok, M., Lelie, P. N., Timmerman, R. J., Chau, K., Van der Pal, H. J. H. Hepatitis E in the Netherlands: imported and endemic. Lancet 341 (1993) 826.Google Scholar
  33. 33.
    Wang, C. H., Flehmig, B., Moeckli, R. Transmission of hepatitis E virus by transfusion? Lancet 341 (1993) 825.Google Scholar

Copyright information

© MMV Medizin Verlag GmbH München 1994

Authors and Affiliations

  • I. Köksal
    • 1
  • K. Aydin
    • 1
  • B. Kardes
    • 1
  • H. Turgut
    • 2
  • F. Murt
    • 2
  1. 1.Dept. of Infectious Diseases, School of MedicineKaradeniz Technical UniversityTrabzon
  2. 2.Dept. of Infectious Diseases, School of MedicineDicle UniversityDiyarbakirTurkey

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