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Intensive Care Medicine

, Volume 22, Issue 3, pp 213–219 | Cite as

Renal effects of low-dose dopamine in patients with sepsis syndrome or septic shock treated with catecholamines

  • T. Lherm
  • G. Troché
  • M. Rossignol
  • P. Bordes
  • J. F. Zazzo
Original

Abstract

Objective

To evaluate the renal effects of low-dose dopamine in patients with sepsis syndrome or septic shock treated with catecholamines.

Design

Prospective, clinical study using sequential periods.

Setting

A 12-bed surgical intensive care unit in a university hospital.

Patients

14 patients with sepsis syndrome and 15 patients with septic shock treated with exogenous catecholamines were studied. They had no diuretic treatment.

Intervention

Two periods of 2 h each with and without 2μg·kg−1·min−1 of dopamine infusion. Hemodynamic and renal data were obtained at the end of each period. Measurements were repeated after 48 h of dopamine infusion in patients with sepsis syndrome. All data were evaluated by the Wilcoxon rank test.

Measurements and results

In patients with sepsis syndrome, diuresis and creatinine clearance increased significantly by 100% and 60%, respectively, during low-dose dopamine infusion without any change in systemic hemodynamics. The renal response to dopamine decreased significantly after 48 h of dopamine infusion (P<0.01). In patients with septic shock treated with catecholamines, no variation of either systemic hemodynamics or renal function was noted during low-dose dopamine infusion.

Conclusion

The renal effects of low-dose dopamine in patients with sepsis syndrome decrease with time. No renal effect of low-dose dopamine was observed in patients with septic shock treated with catecholamines. These findings suggest a desensitization of renal dopaminergic receptors.

Key words

Low dose dopamine Catecholamines Sepsis syndrome Septic shock Renal function Dopaminergic receptors Desensitization 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • T. Lherm
    • 1
  • G. Troché
    • 1
  • M. Rossignol
    • 1
  • P. Bordes
    • 2
  • J. F. Zazzo
    • 1
  1. 1.Departement d'Anesthésie-Réanimation, Hopital Antoine BéclèreUniversité Paris-SudClamart CedexFrance
  2. 2.Département de Biochimie Hôpital Antoine BéclèreUniversité Paris-SudClamart CedexFrance

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