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Effects of fluoride on thyroid hormone biosynthesis. Studies in a highly sensitive test system


In view of the recommendation that fluoride supplements via drinking water or table salt prevent dental caries, we analyzed whether fluoride had antithyroid properties in a sensitive experimental model. Rats were given either 60 or 200 µg/ml fluoride in the drinking water. This raised the serum fluoride concentration from 0.165 to 0.246 in the first and to 0.576 µg/ml in the second instance. Although the higher fluoride dose was near the toxic range, no antithyroid effect was observed. Neither organification of iodine, nor any subsequent step of thyroid hormone biosynthesis (transformation of monoiodotyrosine to diiodotyrosine and then to thyroxine) were affected. Fluoride had no effect on thyroglobulin content of the thyroid gland or on the degree of iodination of thyroglobulin.

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  1. 1.

    Bürgi H, Radvila A, Kohler H, Studer H (1974) Effects of pharmacological doses of iodide on the hyperplastic rat thyroid gland. Roles of intrathyroidal iodide, thyrotropin and thyroglobulin in the Wolff-Chaikoff-phenomenon. Endocrinology 95:388–396

  2. 2.

    Bürgi H, Osterwalder HJ, Kohler H, Studer H (1975) Preferential inhibition by propylthiouracil of diiodotyrosine and thyroxine biosynthesis: a consequence of low thyroglobulin iodination. In: Robbins T (ed) Thyroid Research. Excerpta Medica International Congress Series No 378, Amsterdam, pp 159–161

  3. 3.

    Bürgi H, Siebenhüner L, Miloni E (1984) Fluorine and thyroid gland function. A review of the literature. Klin Wochenschr (in press)

  4. 4.

    Gedalia I, Gross J, Guttman S, Steiner JE, Sulman FG, Weinreb MM (1960) The effects of water fluorination on thyroid function, bones and teeth of rats on a low iodine diet. Arch Int Pharmacodyn Ther 129:116–124

  5. 5.

    Harris NO, Hayes RL (1955) A tracer study of the effect of acute and chronic exposure to sodium fluoride on the thyroid iodine metabolism of rats. J Dent Res 34:470–477

  6. 6.

    Kahl S, Bobek S (1975) Effect of fluoride administration on radiothyroxine turnover in rats. Endocrinologia Polska 26:391–398

  7. 7.

    Korrodi H, Wegmann T, Galletti P, Held HR (1955) Sind bei der Cariesprophylaxe mit Fluor Rückwirkungen auf die Schilddrüse zu erwarten? Schweiz Med Wochenschr 85:1016–1019

  8. 8.

    Korrodi H, Wegmann T, Galletti P, Held HR (1956) Fluor und Schilddrüse. Z Präventivmed 1:285–296

  9. 9.

    Lauber K (1975) Iodine determination in biological material. Kinetic measurement of the catalytic activity of iodide. Anal Chem 47:769–771

  10. 10.

    Regolati B (1957) Studies on intermittent fluoride administration. Helv Odontol Acta 19, Suppl IX: 95–130

  11. 11.

    Schaitt A, Marthaler TM (1977) Determination of small quantities of fluoride in some biological materials. Schweiz Z Zahnheilkunde 87:789–796

  12. 12.

    Schweiz Akademie der Medizinischen Wissenschaften (1981) Kariesprophylaxe durch Fluoridanwendung. Schweiz Ärztezeitung 62:1904

  13. 13.

    Stolc V, Podoba J (1960) Effect of fluoride on the biogenesis of thyroid hormones. Nature 188:855–856

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Supported by grant Nr. 3.848–0.81 of the Swiss National Science Foundation

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Siebenhüner, L., Miloni, E. & Bürgi, H. Effects of fluoride on thyroid hormone biosynthesis. Studies in a highly sensitive test system. Klin Wochenschr 62, 859–861 (1984). https://doi.org/10.1007/BF01712004

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Key words

  • Fluoride
  • Thyroid hormone biosynthesis
  • Thyroglobulin