, Volume 23, Issue 1, pp 55–57 | Cite as

Multifocal osteomyelitis caused byPaecilomyces varioti in a patient with chronic granulomatous disease

  • A. Cohen-Abbo
  • Kathryn M. Edwards
Case Report


This report describes an 18-year-old male patient with chronic granulomatous disease who developed cutaneous nodules and multifocal osteomyelitis with the saprophytic fungusPaecilomyces varioti. After several biopsies the organism was identified. Antifungal susceptibility testing was performed. Combination therapy with amphotericin B and γ-interferon followed by long-term therapy with itraconazole and γ-interferon resulted in a clinical response.


Nodule Interferon Male Patient Clinical Response Amphotericin 
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Multifokale Osteomyelitis durchPaecilomyces varioti bei einem Patienten mit chronischer Granulomatose


Bei einem 18jährigen Patienten mit chronischer Granulomatose traten kutane Knötchen und eine multifokale Osteomyelitis auf, die durch den saprophytischen PilzPaecilomyces varioti bedingt war. Die Identifizierung des Erregers, der auf seine Empfindlichkeit gegenüber Antimykotika getestet wurde, gelang nach Entnahme mehrerer Biopsien. Die Behandlung mit Amphotericin B und gamma Interferon und mit einer Langzeittherapie mit Itraconazol und gamma-Interferon war erfolgreich.


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Copyright information

© MMV Medizin Verlag GmbH München 1995

Authors and Affiliations

  • A. Cohen-Abbo
    • 1
  • Kathryn M. Edwards
    • 1
  1. 1.Division of Infectious Diseases, Dept. of Pediatrics, D-7221 Medical Center NorthVanderbilt University School of MedicineNashvilleUSA

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