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Magnetization transfer by simple sequences of rectangular pulses


On-resonant radio frequency (RF) sequences composed of a train of short rectangular pulses of the same kind were optimized in order to obtain selective saturation of protons with short transverse relaxation times for magnetization transfer purposes. It is demonstrated that the sequences regarded allow a good adaptation to different requirements for magnetization transfer examinations on whole-body imagers. The sequences presented here provide relatively strong saturation of protons with very short transverse relaxation timesT 2≲50 µs, whereas signals from protons with longT 2 to be recorded are hardly influenced in a broad frequency range. The sequences are especially advantageous for applications in pulse files with limited numbers of support points.

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  1. 1.

    Wolff SD, Balaban RS (1989) Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo.Magn Reson Med 10 135.

  2. 2.

    Pike GB, Hu BS, Glover GH, Enzmann DR (1992) Magnetization transfer time-of-flight magnetic resonance angiography.Magn Reson Med 25 372.

  3. 3.

    Miyazaki M, Kojima F, Ichinose N, Onozato Y, Igarashi H (1994) A novel saturation transfer contrast method for 3D time-of-flight magnetic resonance angiography: a slice-selective off-resonance sinc pulse (SORS) technique.Magn Reson Med 29 311.

  4. 4.

    Wolff SD, Chesnick S, Frank JA, Lim KO, Balaban RS (1991) Magnetization transfer contrast MR imaging of the knee.Radiology 179 623.

  5. 5.

    Flamig DP, Pierce WB, Harms SE, Griffey RH (1992) Magnetization transfer contrast in fat-suppressed steady-state three-dimensional MR images.Magn Reson Med 26 122.

  6. 6.

    Hajnal JV, Baudouin J, Oatridge A, Young IR, Bydder GM (1992) Design and implementation of magnetization transfer pulse sequences for clinical use.J Comput Assist Tomogr 16 7.

  7. 7.

    Hu BS, Conolly SM, Wright GA, Nishimura DG, Ma-covski A (1992) Pulsed magnetization transfer contrast.Magn Reson Med 26 231.

  8. 8.

    Balaban RS, Jaffer F, Wen H (1994) Magnetization transfer contrast at 4 Tesla.Abstracts SSMRM Second Meeting, San Francisco, p. 561.

  9. 9.

    Balaban RS, Ceckler TL (1992) Magnetization transfer contrast in magnetic resonance imaging.Magn Reson Quarterly 8 116.

  10. 10.

    Henkelmann RM, Huang X, Xiang QS, Stanisz GJ, Swanson SD, Bronskill MJ (1993) Quantitative interpretation of magnetization transfer.Magn Reson Med 29 759.

  11. 11.

    Koenig SH, Brown RD, Ugolini R (1993) Magnetization transfer in cross-linked bovine serum albumin solutions at 200 MHz: a model for tissue.Magn Reson Med 29 311.

  12. 12.

    Swanson SD (1993) Design of optimal rf saturation pulses for MTC imaging.Abstracts SSMRM Twelfth Annual Meeting, New York, p. 176.

  13. 13.

    Schwarzbauer C, Zange J, Deichmann R, Nöth U, Adolf H, Haase A (1994) High speed imaging of the magnetization transfer constant.Abstracts SSMRM Second Meeting, San Francisco, p. 875.

  14. 14.

    Hore PJ (1983) Solvent suppression in Fourier transform nuclear magnetic resonance.J Magn Reson 55 283.

  15. 15.

    Schick F, Forster J, Pfeffer M, Lutz O (1994) Pulsed magnetization transfer for imaging and spectroscopic applications on whole-body imagers.MAGMA 2 127.

  16. 16.

    Wu X-L, Xu P, Friedrich J, Freeman R (1989) Selective excitation with the DANTE sequence: The baseline syndrom.J Magn Reson 81 206.

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Correspondence to Otto Lutz.

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Forster, J., Schick, F., Pfeffer, M. et al. Magnetization transfer by simple sequences of rectangular pulses. MAGMA 3, 83–93 (1995). https://doi.org/10.1007/BF01709851

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  • magnetization transfer
  • pulse sequences
  • selective saturation