Hepatitis C virus infection in pregnancy and the risk of mother-to-child transmission

  • S. Polywka
  • H. Feucht
  • B. Zöllner
  • R. Laufs


The risk of vertical transmission of the hepatitis C virus (HCV) from infected mothers to their children during pregnancy and delivery was determined in 120 children born to HCV-positive mothers. Methods included enzyme immunoassay and immunoblot for detection of HCV antibodies and reverse transcription polymerase chain reaction (RT-PCR) for detection of viral RNA. Six (5%) children were perinatally infected with HCV as shown by RT-PCR. None of the infected children had clinical signs of hepatitis. None of the pregnancies was complicated by abortion, stillbirth, premature birth, or malformation of the child. Special concern was given to the possibility of HCV transmission via breast milk. In no breast milk sample obtained from 34 HCV-infected mothers was HCV RNA detected. These observations indicate that HCV infection is not necessarily a contraindication for breast-feeding.


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  1. 1.
    Alter M: Transmission of hepatitis C virus — route, dose, and titer. New England Journal of Medicine 1994, 330: 784–786.Google Scholar
  2. 2.
    Polywka S, Laufs R: Hepatitis C virus antibodies among different groups at risk and patients with suspected non-A, non-B hepatitis. Infection 1991, 19: 81–84.Google Scholar
  3. 3.
    Feucht HH, Polywka S, Zöllner B, Laufs R: Greater amount of HCV-RNA in tears compared to blood. Microbiology and Immunology 1994, 38: 157–158.Google Scholar
  4. 4.
    Ogasawara S, Kage M, Kosai KI, Shimamatsu K, Kojiro M: Hepatitis C virus RNA in saliva and breastmilk of hepatitis C carrier mothers. Lancet 1993, 341: 561.Google Scholar
  5. 5.
    Kudesia G, Ball G, Irving WL: Vertical transmission of hepatitis C. Lancet 1995, 345: 1122.Google Scholar
  6. 6.
    Maggiore G, Ventura A, De Giacomo C, Silini E, Cerino A, Mondelli MU: Vertical transmission of hepatitis C. Lancet 1995, 345: 1122.Google Scholar
  7. 7.
    Uehara S, Abe Y, Saito T, Yoshida Y, Wagatsuma S, Okamura K, Yajima A, Mandai M: The incidence of vertical transmission of hepatitis C virus. Tohoku Journal of Experimental Medicine 1993, 171: 195–202.Google Scholar
  8. 8.
    Matsubara T, Sumazaki R, Takita H: Mother-to-infant transmission of hepatitis C virus: a prospective study. European Journal of Pediatrics 1995, 154: 973–978.Google Scholar
  9. 9.
    Pipan C, Amici S, Astori G, Ceci GP, Botta GA: Vertical transmission of hepatitis C virus in low-risk pregnant women. European Journal of Clinical Microbiology & Infectious Diseases 1996, 15: 116–120.Google Scholar
  10. 10.
    Zanetti AR, Tanzi E, Paccagnini S, Principi N, Pizzocolo G, Caccamo ML, D'Amico E, Cambiè G, Vecchi L, and the Lombardy Study Group on Vertical Transmission: Mother-to-infant transmission of hepatitis C virus. Lancet 1995, 345: 289–291.Google Scholar
  11. 11.
    Lam JP, McOmish F, Burns SM, Yap PL, Mok JY, Simmonds P: Infrequent vertical transmission of hepatitis C virus. Journal of Infectious Diseases 1993, 167: 572–576.Google Scholar
  12. 12.
    Feucht HH, Zöllner B, Polywka S, Laufs R: Study on reliability of commercially available hepatitis C virus antibody tests. Journal of Clinical Microbiology 1995, 33: 620–624.Google Scholar
  13. 13.
    Chomczynski P, Sacchi N: Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 1987, 162: 156–159.Google Scholar
  14. 14.
    Reuter D, Polywka S, Iske L, Feucht HH, Laufs R: Close correlation between hepatitis C virus serology and polymerase chain reaction in chronically infected patients, Infection 1992, 20: 20–323.Google Scholar
  15. 15.
    Moriya T, Sasaki F, Mizui M, Ohno N, Mohri H, Mishiro S, Yoshizawa H: Transmission of hepatitis C virus from mothers to infants: its frequency and risk factors revisited. Biomedicine and Pharmacotherapy 1995, 49: 59–64.Google Scholar
  16. 16.
    Ohto H, Terazawa S, Sasaki N, Sasaki N, Hino K, Ishiwata C, Kako M, Ujiie N, Endo C, Matsui A, Okamoto H, Mishiro S, and the Vertical Transmission of Hepatitis C Virus Collaborative Study Group: Transmission of hepatitis C virus from mothers to infants. New England Journal of Medicine 1994, 330: 744–750.Google Scholar
  17. 17.
    Lin HH, Kao JH, Hsu HY, Ni YH, Chang MH, Huang SC, Hwang LH, Chen PJ, Chen DS: Absence of infection in breast-fed infants born to hepatitis C virus-infected mothers. Journal of Pediatrics 1995, 126: 589–591.Google Scholar
  18. 18.
    Lazizi Y, Dubreuil P, Pillot J: Excess HBcAg in Hbc antibody negative chronic hepatitis B virus carriers. Hepatology 1993, 17: 966–970.Google Scholar
  19. 19.
    Manzini P, Saracco G, Cerchier A, Riva C, Musso A, Ricotti E, Palomba E, Scolfaro C, Verme G, Bonino F, Tovo PA: Human immunodeficiency virus infection as risk factor for mother-to-child hepatitis C virus transmission: persistence of anti-hepatitis C virus in children is associated with the mother's anti-hepatitis C virus immunoblotting pattern. Hepatology 1995, 21: 328–332.Google Scholar

Copyright information

© MMV Medizin Verlag GmbH 1997

Authors and Affiliations

  • S. Polywka
    • 1
  • H. Feucht
    • 1
  • B. Zöllner
    • 1
  • R. Laufs
    • 1
  1. 1.Institute for Medical Microbiology and ImmunologyUniversity Hospital EppendorfHamburgGermany

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