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Acute pulmonary edema associated with transfusion of packed red blood cells

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Abstract

We experienced a patient who suffered noncardiogenic acute pulmonary edema after transfusion of packed red blood cells which contained antigranulocyte antibodies. The data suggested that complement activation and the release of polymorphonuclear protease were involved in the pathogenesis of the complication in the present patient. Furthermore, blood coagulative system was also activated after the transfusion. The underlying mechanisms of the complication are discussed.

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References

  1. 1.

    Popovsky MA, Abel MD, Moore SB (1983) Transfusion-related acute lung injury associated with passive transfer of antileukocyte antibodies. Am Rev Respir Dis 128:185–189

  2. 2.

    Neumann S, Hennrich N, Gunzer G, Hennrich N, Lang H (1984) “PMN-elastase assay”: enzyme immunoassay for human polymorphonuclear elastase complexed with α1-protease inhibitor. J Clin Chem Biochem 22:693–697

  3. 3.

    Gans ROB, Duurkens VAM, van Zundert AA, Hoorntje SJ (1988) Transfusion-related acute lung injury. Intensive Care Med 14:654–657

  4. 4.

    Anderson BO, Brown JM, Bensard DD, Grosso MA, Banerjee A, Patt A, Whitman GJR, Harken AH (1990) Reversible lung neutrophil accumulation can cause lung injury by elastase-mediated mechanisms. Surgery 108:262–268

  5. 5.

    Westaby S (1986) Mechanism of membrane damage and surfactant depletion in acute lung injury. Intensive Care Med 12:2–5

  6. 6.

    Cochrane CG, Spragg RG, Devak SD, Cohen AB, McGuire WW (1983) The presence of neutrophil elastase and evidence of oxidant activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Am Rev Respir Dis 127 [Suppl]: S25-S27

  7. 7.

    Shapiro BA, Cane RD (1981) Metabolic malfunction of lung: noncardiogenic edema and adult respiratory distress syndrome. Surg Annu 13:271–298

  8. 8.

    Grimminger F, Kreusler B, Schneider U, Witzleben EV, Walmarath D, Neppert J, Seeger W (1991) Human leukoagglutinating antibody evokes cooperative leukotriene synthesis in pulmonary microvasculature: model of transfusion-related acute lung injury. Circ Res 68: 503–512

  9. 9.

    Schraufstätter IU, Revak SD, Cochrane CG (1984) Protease and oxidants in experimental pulmonary inflammatory injury. J Clin Invest 73:1175–1184

  10. 10.

    Bone RC (1992) Phospholipids and their inhibitors: a critical evaluation of their role in the treatment of sepsis. Crit Care Med 20:884–890

  11. 11.

    Bone RC, Frances PB, Peirce AK (1976) Intravascular coagulation associated with the adult respiratory distress syndrome. Am J Med 61:585–589

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Correspondence to M. Kawamata.

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Kawamata, M., Miyabe, M., Omote, K. et al. Acute pulmonary edema associated with transfusion of packed red blood cells. Intensive Care Med 21, 443–446 (1995). https://doi.org/10.1007/BF01707415

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Key words

  • Transfusion
  • Non-cardiogenic
  • Pulmonary edema
  • Antibody
  • Antigranulocyte