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A rapidly progressing lethal case of neuroleptic malignant syndrome

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Abstract

A fast progressing lethal case of neuroleptic malignant syndrome (NMS) complicated by disseminated intravascular coagulation (DIC) is presented. The fulminant course is infrequent and relates NMS to malignant hyperthermia. Muscular relaxation in combination with fluid load dramatically decreased the temperature, but the catastrophic course of this case was so advanced that the currently recommended treatment of NMS was impossible.

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References

  1. 1.

    Caroff SN (1980) The neuroleptic malignant syndrome. J Clin Psychiatry 41:79–83

  2. 2.

    Caroff SN, Rosenberg H, Gerber JC (1983) Neuroleptic malignant syndrome and malignant hyperthermia (letter). Lancet I:244

  3. 3.

    Caroff SN, Rosenberg H, Fletcher JE, Heiman-Patterson TD, Mann SC (1987) Malignant hyperthermia susceptibility in neuroleptic malignant syndrome. Anesthesiology 67:20–25

  4. 4.

    Johnson MD, Newman JH, Baxter JW (1988) Neuroleptic malignant syndrome presenting as adult respiratory distress syndrome and disseminated intravascular coagulation. South Med J 81:543–545

  5. 5.

    Granato JE, Barney JS, Ringel A, Karim AH, Krumholz A, Coyle J, Adler S (1983) Neuroleptic malignant syndrome: successful treatment with dantrolene and bromocriptine. Ann Neurol 14:89–90

  6. 6.

    Henderson VW, Wooten GF (1981) Neuroleptic malignant syndrome: A pathogenic role for dopamine receptor bockade? Neurology 31:132–137

  7. 7.

    Peebles-Brown AE (1985) Hyperpyrexia following psychotropic drug overdose. Anaesthesia 40:1097–1099

  8. 8.

    Tackley RM, Tregaskis B (1987) Fatal disseminated intravascular coagulation following a monoamine oxidase inhibitor/tricyclic interaction. Anaesthesia 42:760–763

  9. 9.

    Scott RJ (1989) Fatal thermal injury. Med J Aust 150:215–217

  10. 10.

    Mueller PS, Vester JW, Fermaglich J (1983) Neuroleptic malignant syndrome. Successful treatment with bromocriptine. JAMA 249:386–388

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Author information

Correspondence to Dr. P. Lenler-Petersen.

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Lenler-Petersen, P., Hansen, B.D. & Hasselstrøm, L. A rapidly progressing lethal case of neuroleptic malignant syndrome. Intensive Care Med 16, 267–268 (1990). https://doi.org/10.1007/BF01705164

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Key words

  • Neuroleptic malignant syndrome
  • Disseminated intravascular coagulation
  • Hyperthermia