Intensive Care Medicine

, Volume 20, Issue 3, pp 187–192 | Cite as

Prevention of Gram negative noscomial bronchopneumonia by intratracheal colistin in critically ill patients

Histologic and bacteriologic study
  • J. J. Rouby
  • P. Poète
  • E. Martin de Lassale
  • M. H. Nicolas
  • L. Bodin
  • V. Jarlier
  • A. M. Korinek
  • P. Viars



To evaluate the efficiency of intratracheal colistin in preventing nosocomial bronchopneumonia (BPN) in the critically ill.


Study evaluating the clinical incidence of nosocomial BPN in 2 groups of critically ill patients who receive or did not receive intratracheal colistin. BPN was assessed clinically in survivors and histologically in nonsurvivors.


A 14-bed surgical intensive care unit.


598 consecutive critically ill patients were studied during a prospective non-randomized study over a 40-month period.


251 patients — 31 non-survivors and 220 survivors — did not receive intratracheal colistin and 347 — 42 non-survivors and 305 survivors — received intratracheal colistin for a 2-week period (16000000 units per 24h).

Measurements and results

The incidence of nosocomial BPN was evaluated clinically in survivors, using repeated protected minibronchoalveolar lavages, and histologically in non-survivors via an immediate postmortem pneumonectomy (histologic and semi-quantitative bacteriologic analysis of one lung). The clinical incidence of nosocomial BPN was of 37% in coli (−) survivors and of 27% in coli (+) survivors (p<0.01). This result was histologically confirmed in non-survivors, where the incidence of histologic BPN was of 61% in coli (−) patients and of 36% in coli (+) patients (p<0.001). Emergence of BPN due to colistin-resistant micro-organisms was not observed. Because colistin was successful in preventing Gram-negative BPN and did not change the absolute number of Gram-positive BPN, the proportion of BPN caused bystaphylococcus species was higher in group coli (+) patients (33% vs 16%). Mortality was not significantly influenced by the administration of colistin.


This study suggests that the administration of intratracheal colistin during a 2-week period significantly reduces the incidence of Gram-negative BPN without creating an increasing number of BPN due to colistin-resistant micro-organism.

Key words

Nosocomial bronchopneumonia Mechanical ventilation Intratracheal colistin 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • J. J. Rouby
    • 1
  • P. Poète
    • 1
  • E. Martin de Lassale
    • 1
  • M. H. Nicolas
    • 1
  • L. Bodin
    • 1
  • V. Jarlier
    • 1
  • A. M. Korinek
    • 1
  • P. Viars
    • 1
  1. 1.Unité de Réanimation Chirurgicale, Département d'Anesthésie, Laboratoire d'Anatomo-Pathologie et Laboratoire de Bactériologie, Hôpital de la Pitié-SalpétrièreUniversité Paris VIParis Cedex 13France

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