Virus Genes

, Volume 8, Issue 3, pp 275–278 | Cite as

Nucleotide sequence of the P1 region of serotype Asia1 foot-and-mouth disease virus

  • Yehuda Stram
  • Oded Laor
  • Thea Molad
  • Dalia Chai
  • Douglas Moore
  • Hagai Yadin
  • Yechiel Becker
Article
Received:
Accepted:

Abstract

Differences in the amino acid sequence of foot-and-mouth disease virus (FMDV) virion proteins (VP) among the various FMDV serotypes, particularly in the VP1 polypeptide, are the basis for antigenic diversity of this virus group. This phenomenon provides the basis for type diagnosis of FMDV by the polymerase chain reaction (PCR). In order to specifically identify the Asia1 FMDV serotype by PCR, the nucleotide sequence of its P1-coding region was determined. The sequence exhibited over 70% homology with the P1 gene segment of type O1k. The deduced amino acid sequence shares 79% homology with that of the P1 region of serotype O1k.

Keywords

Polymerase Chain Reaction Nucleotide Amino Acid Sequence Nucleotide Sequence Polypeptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Yehuda Stram
    • 1
  • Oded Laor
    • 2
  • Thea Molad
    • 1
  • Dalia Chai
    • 1
  • Douglas Moore
    • 3
  • Hagai Yadin
    • 1
  • Yechiel Becker
    • 2
  1. 1.The Kimron Veterinary InstituteBet-DaganIsrael
  2. 2.Department of Molecular Virology, Faculty of MedicineThe Hebrew University of JerusalemIsrael
  3. 3.Plum Island Animal Disease CenterAgricultural Research Service, USDAGreenportUSA

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