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Expression of the collagen-like putative oncoprotein ofHerpesvirus saimiri in transformed T cells

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Abstract

Herpesvirus saimiri induces acute lymphomas and leukemias in New World primates and rabbits. Previous work revealed that a highly oncogenic group C strain 484–77 encodes and expresses a bicistronic mRNA in tumor-derived T cells and the first open reading frame (orf1) is highly homologous to collagen. With the aid of an antibody against a synthetic orf1 peptide, we now report that the orf1 collagen-like protein is expressed in rabbit tumor derived cell lines and in vitro transformed human and monkey T cells. The orf1 protein is expressed in vivo, as indicated by specific antibodies detected in the serum from a tumor-bearing rabbit.

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Correspondence to Dr. Peter G. Medveczky.

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Medveczky, M.M., Geck, P., Vassallo, R. et al. Expression of the collagen-like putative oncoprotein ofHerpesvirus saimiri in transformed T cells. Virus Genes 7, 349–365 (1993). https://doi.org/10.1007/BF01703391

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Key words

  • herpesvirus saimiri
  • oncogene
  • collagen
  • bicistronic eukaryotic mRNA
  • T cells
  • CD8