Classification system and case definitions ofToxoplasma gondii infection in immunocompetent pregnant women and their congenitally infected offspring
- 195 Downloads
Classification systems and case definitions provide the foundations upon which clinical and epidemiological studies are based. The European Research Network on Congenital Toxoplasmosis acknowledged the lack of such a system or definitions within its field of interest and established a working group to address the issue. CongenitalToxoplasma gondii infection was defined as occurring in four separate patient groups: pregnant women, fetuses, infants, and individuals > 1 year of age. The likelihood ofToxoplasma gondii infection was separated into five mutually exclusive categories: definite, probable, possible, unlikely, and not infected. Inclusion within a specific category is dependent upon the case definition, which is in turn derived from criteria based on serological, parasitological, and clinical information. Notes are included within the classification not only to clarify the definitions, but also to improve the reliability and quality of diagnosis. The goal is to construct a system that encompasses all aspects of congenital toxoplasmosis, which is applicable to different countries and health services, suitable for large epidemiological studies, aids the diagnosis and management of individual cases, and lends itself to computerisation.
Unable to display preview. Download preview PDF.
- 1.Ho-Yen DO, Joss AWL: Human toxoplasmosis. Oxford University Press, Oxford 1993, p. 56–75.Google Scholar
- 3.Remington JS, Mcleod R, Desmonts SG: Toxoplasmosis. In: Remington JS, Klein JO (ed): Infectious diseases of the fetus and newborn infant. WB Saunders, Philadelphia, 1995, p. 140–267.Google Scholar
- 4.Wilson CB, Remington JS, Staquos Reynolds DW: Development of adverse sequelae in children born with subclinical congenital toxoplasma infection. Paediatrics 1980, 66: 767–774.Google Scholar
- 5.Koppe JG, Loewer-Sieger DH, De Roever-Bonner H: Results of 20-year follow-up congenital toxoplasmosis. Lancet 1986, i: 254–256.Google Scholar
- 7.Sabin AB, Feldman HA: Dyes as microchemical indicators of a new immunity phenomenon affecting a potozoan parasite (Toxoplasma). Science 1948, 108: 660–663.Google Scholar
- 8.Hedman K, Lappalainan M, Seppaia E, Makela O: Recent primary toxoplasma infection indicated by a low avidity of specific IgG. Journal of Infectious Diseases 1989, 59: 736–740.Google Scholar
- 11.Centers for Disease Control: Revised classification system for HIV infection and expanded surveillance case definitions for AIDS among adolescents and adults. Morbidity and Mortality Weekly Report 1992, 42: 1–19.Google Scholar
- 12.Desmonts G, Daffos F, Forestier F, Capella-Pavlousky M, Thulliez P, Chartier M: Prenatal diagnosis of congenital toxoplasmosis. Lancet 1985, i: 500–504.Google Scholar