Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The effect of DDT on spermatogenesis of the juvenile rat

Summary

Juvenile male rats of Wistar/Han strain were fed DDT suspended in olive oil. They received either 500 mg/kg at the 4th and 5th or 200 mg/kg daily at the 4th till 23rd day of life. After certain intervals the testes were examined histologically, and at the 60th and 90th day of life fertility was proved. The spermatogenetic cells showed an increase of the physiological degeneration in the course of spermatogenesis and a decrease of their total number. The number of Leydig cells was diminished. In parallel, the litters of normal female rats mated to treated males were smaller than those of controls. The hypothesis is suggested that the damage of the seminiferous epithelium can be explained by a lack of local testosterone.

This is a preview of subscription content, log in to check access.

References

  1. AN DER LAN, H., Zbltt. Bakt. I. Abt. 210:234(1969)

  2. BRYSON, M., DRAPER, Ci, HARRIS, J.R., BIDDULPH, C. Adv. Chem. Ser. I, 232 (1950)

  3. BURLINGTON, H. and V.F. LINDMANN, Proc. Soc. Exp. Biol. Med. 74: 48 (1950)

  4. COTTRELL, T.L.C. and N.J. HECKEL, J. Urol. 81:551 (1959)

  5. DEICHMANN, W. and M.C. KEPLINGER, 5th Ann. Meet. Soc. Toxicol. Virginia 1966

  6. DEICHMANN, W., MacDONALD, W.E., BEASLEY, A.G. and D. CUBIT, Ind, J. Med. 40:10 (1971)

  7. FEASTER, I. P. and D. STEVENS, J. Nutri. 102:523 (1972)

  8. GELLERT, D.J., HEINRICHS, W. L. and D. S. SWERDLOFF, Endocrin. 91: 1095 (1972)

  9. HAUG, H., Zschr. Anat. Entw. Gesch. 118:302 (1955)

  10. HEESE, K., STRÖDTER, D. und D. SCHRECK, Inaug. Diss. Gießen 1973

  11. HILSCHER, W. and B. HILSCHER, Morph. Asp. Androl. 1:17 (1971)

  12. KUPFER, D., Ann. N.Y. Acad. Sci. 160:244 (1969)

  13. LEBLOND, C.P. and Y. CLERMONT, Am. J. Anat. 90: 167 (1952)

  14. De ROOIJ, D.G. and M.F. KRAMER, Zschr. Zellforsch. 92: 400 (1968)

  15. ROOSEN-RUNGE, E. and D. ANDERSON, Zechr. Zellforsh. 41:221 (1955)

  16. SMITH, J. and F. THOMAS, Toxicol. Appl. Pharm. 23: 159 (1972)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Krause, W., Hamm, K. & Weissmüller, J. The effect of DDT on spermatogenesis of the juvenile rat. Bull. Environ. Contam. Toxicol. 14, 171–179 (1975). https://doi.org/10.1007/BF01701310

Download citation

Keywords

  • Waste Water
  • Testosterone
  • Water Management
  • Water Pollution
  • Leydig Cell