Evaluation of the susceptibility of pathogenicCandida species to fluconazole

  • J. Bille
  • M. P. Glauser
  • Fluconazole Global Susceptibility Study Group


A fluconazole 25 ug disk diffusion test was used to test 2230 consecutively isolatedCandida strains from 42 different hospital laboratories in 23 countries. Ninety seven percent of 1634Candida albicans isolates and 83.4% of 596 non-Candida albicans isolates were susceptible to fluconazole, applying the proposed breakpoints (≥26 mm for susceptible strains and 18–25 mm for dosedependent susceptible strains). This is the first hospital laboratory study to evaluate a large number and wide range of sequentialCandida isolates from patients with all types of hospital infections. The fluconazole disk diffusion test appears to be a low-cost, reproducible, and accurate means of assessing the in vitro susceptibility ofCandida isolates.


Internal Medicine Laboratory Study Fluconazole Disk Diffusion Susceptible Strain 
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Copyright information

© MMV Medizin Verlag GmbH 1997

Authors and Affiliations

  • J. Bille
    • 1
  • M. P. Glauser
    • 2
  • Fluconazole Global Susceptibility Study Group
  1. 1.Institute of MicrobiologyCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  2. 2.Division of Infectious Disease, Department of Internal MedicineCentre Hospitalier Universitaire VaudoisLausanneSwitzerland

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