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Annals of Hematology

, Volume 70, Issue 4, pp 215–221 | Cite as

Iron status in young Danish men and women: a population survey comprising 548 individuals

  • N. Milman
  • J. O. Clausen
  • R. Jordal
Original Article

Abstract

Iron status was assessed by measurement of serum (S-) ferritin and hemoglobin (Hb) in 548 randomly selected healthy Danes (264 men, 284 women) with a median age of 25 years (range 16–31). S-ferritin values in men displayed a gradual increase with age, and at all ages, men had higher values than women. Iron deficiency (i.e., S-ferritin < 16 μg/l) was observed in 0.8%; none had iron deficiency anemia (i.e., S-ferritin <16μg/l and Hb<129g/l). Daily iron supplementation was used by 15.5%. The frequency of iron deficiency was 0% in supplement users vs 0.9% in nonusers. The frequency of preclinical hereditary hemochromatosis was 0.38%. There was a slight insignificant increase in S-ferritin values of women with age. Iron deficiency was observed in 14.7% of 16- to 19-year-olds, in 9.2% of 20- to 24-year-olds, and in 8.6% of 25- to 31-year-old women (p<0.01), and iron deficiency anemia (i.e., S-ferritin <16μg/l and Hb <121 g/l) in 14.7%, 3.4%, and 3.7%, respectively (p<0.01). Daily iron supplementation was used by 21.5%. The frequency of iron deficiency in users was 4.9% vs. 10.8% in nonusers, and the frequency of iron deficiency anemia 1.6% in users vs. 5.8% in nonusers. The results indicate a satisfactory iron status in young men. There is a high frequency of iron deficiency in young women, suggesting that preventive measures should be considered in this risk group.

Key words

Ferritin Hemoglobin Iron metabolism Iron supplementation Men Women 

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References

  1. 1.
    Hallberg L (1982) Iron nutrition and food iron fortification. Semin Hematol 19:31–41PubMedGoogle Scholar
  2. 2.
    Milman N, Heitmann BL, Lyhne N, Rosdahl N, Jensen KH, Graudal N (1993) Iron status in 1113 Danish men and women aged 35–65 years. Relation to dietary and supplemental iron intake. Scand J Nutr 37:98–103Google Scholar
  3. 3.
    Milman N, Kirchhoff M (1991) Iron stores in 1433, 30- to 60- year-old Danish males. Evaluation by serum ferritin and haemoglobin. Scand J Clin Lab Invest 51:635–641PubMedGoogle Scholar
  4. 4.
    Milman N, Kirchhoff M (1992) Iron stores in 1359, 30- to 60- year-old Danish women: evaluation by serum ferritin and hemoglobin. Ann Hematol 64:22–27PubMedGoogle Scholar
  5. 5.
    Milman N, Graudal N, Juul-Jørgensen B, Bentzon MW (1994) Calibration of the Amersham Ferritin RIA kit using the WHO human liver ferritin international standard 80/60. Eur J Clin Chem Clin Biochem 32:41–42PubMedGoogle Scholar
  6. 6.
    Milman N, Bentzon MW, Graudal N, Juul-Jørgensen B (1993) Statistical pitfalls in the comparison between two commercial serum ferritin kits, Pharmacia and Amersham. Dan Med Bull 40:508–510PubMedGoogle Scholar
  7. 7.
    Walters GO, Miller FM, Worwood M (1973) Serum ferritin concentration and iron stores in normal subjects. J Clin Pathol 26:770–772PubMedGoogle Scholar
  8. 8.
    Cook JD, Lipschitz DA, Miles LEM, Finch CA (1974) Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr 1974; 27:681–687Google Scholar
  9. 9.
    Worwood M. Laboratory determination of iron status. In: Brock JH, Halliday JW, Pippard MJ, Powell LW (eds) Iron metabolism in health and disease. WB Saunders, London, pp 449–476Google Scholar
  10. 10.
    Milman N, Backer V, Laursen EM, Graudal N, Ibsen KK, Jordal R (1994) Serum ferritin in children and adolescents. Results from population surveys in 1979 and in 1986 comprising 1312 individuals. Eur J Haematol 53:16–20PubMedGoogle Scholar
  11. 11.
    Hercberg S, Preziosi P, Renaudier P, Galan P, Christides JP, Devanlay M, Potier de Courcy G, Papoz L, Dupin H (1990) Evaluation du statut en fer et en folates d'un echantillon representatif de la population d'un departement de la region parisienne. Colloque INSERM 197:39–46Google Scholar
  12. 12.
    Green R, Charlton R, Seftel H, Bothwell T, Mayet F, Adams B, Finch CA Layrisse M (1968) Body iron excretion in man. A collaborative study. Am J Med 45:336–353PubMedGoogle Scholar
  13. 13.
    Wiggers P, Dalhøj J, Kiær H, Ring-Larsen H, Petersen PH, Blaabjerg O et al. (1991) Screening for haemochromatosis: prevalence among Danish blood donors. J Intern Med 230:265–270PubMedGoogle Scholar
  14. 14.
    Haraldsdottir J, Holm L, Jensen H, Møller A (1987) Dietary habits in Denmark 1985. Who eats what. National Food Agency of Denmark. Publication no. 154Google Scholar
  15. 15.
    Milman N, Kirchhoff M, Jørgensen T (1992) Iron status markers, serum ferritin and hemoglobin in 1359 Danish women in relation to menstruation, hormonal contraception, parity, and postmenopausal hormone treatment. Ann Hematol 65:96–102PubMedGoogle Scholar
  16. 16.
    Hallberg L, Rossander-Hultén L (1991) Iron requirements in menstruating women. Am J Clin Nutr 54:1047–1058PubMedGoogle Scholar
  17. 17.
    Nutrition recommendations (1989) National Food Agency of Denmark, Publication no. 182Google Scholar
  18. 18.
    Milman N, Rosdahl N, Lyhne N, Jørgensen T, Graudal N (1993) Iron status in Danish women aged 35–65 years. Relation to menstruation and method of contraception. Acta Obstet Gynecol Scand 72:601–605PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • N. Milman
    • 1
  • J. O. Clausen
    • 1
  • R. Jordal
    • 1
  1. 1.Department of MedicineØresund HospitalHørsholmDenmark

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