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Serum α2-HS glycoprotein concentration in patients with hematological malignancies

A follow-up study


We observed significantly reduced serum α2-HS glycoprotein concentrations in patients with acute lymphocytic, acute nonlymphocytic, chronic granulocytic and chronic myelomonocytic leukemias, Hodgkin's and non-Hodgkin's lymphomas, myelofibrosis, and multiple myeloma, but not in patients with chronic lymphocytic leukemia and polycythemia vera, as compared with healthy controls. We followed the serum level of the protein for 18 months. Patients with infectious complications, those receiving cytostatic treatment, and those in the preterminal period had further reduced serum α2-HS glycoprotein levels. The reduction of serum α2-HS glycoprotein concentration was primarily due to decreased production caused by infiltration of the liver, a hepatotoxic effect of cytostatic treatment, and, to a lesser degree, to increased consumption. We found statistically significant negative correlations between serum α2-HS glycoprotein concentration and erythrocyte sedimentation rate, serum aspartate aminotransferase and alkaline phosphatase activities, and IgG and IgM concentrations. The determination of the α2-HS glycoprotein concentration is useful for the assessment and follow-up of the clinical status and therapy of patients with hematological malignancies and also has prognostic significance.

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Correspondence to L. Kalabay.

Additional information

This work was supported by the Hungarian Academy of Sciences OTKA No. 161

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Kalabay, L., Cseh, K., Benedek, S. et al. Serum α2-HS glycoprotein concentration in patients with hematological malignancies. Ann Hematol 63, 264–269 (1991).

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Key words

  • α2- HS glycoprotein
  • Leukemias
  • Lymphomas
  • Myelofibrosis
  • Multiple myeloma
  • Polycythemia vera