Annals of Hematology

, Volume 65, Issue 2, pp 106–109 | Cite as

Elliptocytosis associated with an abnormal α glycophorin

  • Y. -Q. Lu
  • J. -F. Liu
  • C. -H. Huang
  • O. O. Blumenfeld
  • R. S. Schwartz
  • C. Lawrence
  • R. L. Nagel
Case Report


A case of elliptocytosis associated with an undescribed abnormal α glycophorin (αGP) is reported. Using immunoblotting techniques, a clear-cut minor band 6′ was detected emerging just behind the monomer of δGP (band 6) when probed with anti-α GP antiserum. It also reacted with anti-peptide C antiserum, suggesting that this new band with a molecular weight of 24 K is related to the structural alteration of αGP and not δGP. The erythrocyte membrane proteins of the patient exhibited a quite normal pattern, with a normal α spectrin/ Β spectrin ratio, but the reaction with anti-protein 4·1 serum confirmed the increase in proteolytic susceptibility of her protein 4·1. The results of DNA mapping implied that the abnormality may be due to a short deletion of the heterozygote. The significance of deviation involving the α GP and protein 4·1 to the elliptocytic change of erythrocyte shape is briefly discussed.


Elliptocytosis Glycophorin Protein 4·1 Erythrocyte membrane 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Y. -Q. Lu
    • 1
  • J. -F. Liu
    • 1
  • C. -H. Huang
    • 2
  • O. O. Blumenfeld
    • 4
  • R. S. Schwartz
    • 3
  • C. Lawrence
    • 3
  • R. L. Nagel
    • 3
  1. 1.Department of BiochemistryHunan Medical UniversityHunanPeople's Republic of China
  2. 2.Laboratory of Molecular BiologyHunan Medical UniversityChangshaPeople's Republic of China
  3. 3.Division of Hematology, Department of MedicineAlbert Einstein College of MedicineBronxUSA
  4. 4.Department of BiochemistryAlbert Einstein College of MedicineBronxUSA

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