Elliptocytosis associated with an abnormal α glycophorin
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A case of elliptocytosis associated with an undescribed abnormal α glycophorin (αGP) is reported. Using immunoblotting techniques, a clear-cut minor band 6′ was detected emerging just behind the monomer of δGP (band 6) when probed with anti-α GP antiserum. It also reacted with anti-peptide C antiserum, suggesting that this new band with a molecular weight of 24 K is related to the structural alteration of αGP and not δGP. The erythrocyte membrane proteins of the patient exhibited a quite normal pattern, with a normal α spectrin/ Β spectrin ratio, but the reaction with anti-protein 4·1 serum confirmed the increase in proteolytic susceptibility of her protein 4·1. The results of DNA mapping implied that the abnormality may be due to a short deletion of the heterozygote. The significance of deviation involving the α GP and protein 4·1 to the elliptocytic change of erythrocyte shape is briefly discussed.
KeywordsElliptocytosis Glycophorin Protein 4·1 Erythrocyte membrane
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