Annals of Hematology

, Volume 66, Issue 3, pp 157–159 | Cite as

Severe aplastic anemia associated with seronegative community-acquired hepatitis C virus infection

  • A. Gruber
  • L. Grillner
  • H. Norder
  • L. Magnius
  • M. Björkholm
Case Report


Aplastic anemia (AA) is a rare complication of viral hepatitis affecting mainly children or young adults. Most reported cases have been associated with community-acquired non-A, non-B hepatitis, but hepatitis A and B have also been implicated in a few patients. We report on a 43-year-old woman with severe AA, in association with acute hepatitis C virus (HCV) infection, diagnosed by detection of HCV RNA by the polymerase chain reaction technique. Her AA was successfully treated with anti-thymocyte globulin and cyclosporin A. The hepatitis C progressed to chronic disease but, despite a follow-up time of 2 years, the patient still has no detectable anti-HCV antibodies, as evaluated with a secondgeneration anti-HCV assay.

Key words

Aplastic anemia Hepatitis C Antithymocyte globulin Cyclosporin A Immunosuppression 


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • A. Gruber
    • 1
  • L. Grillner
    • 2
  • H. Norder
    • 3
  • L. Magnius
    • 3
  • M. Björkholm
    • 1
  1. 1.Division of Medicine, Section of Hematology and ImmunologyKarolinska HospitalStockholmSweden
  2. 2.Department of Clinical Microbiology, Section of VirologyKarolinska HospitalSweden
  3. 3.National Bacteriological LaboratoryStockholmSweden

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