Annals of Hematology

, Volume 64, Issue 3, pp 123–127

Low-dose interferon-alpha in stage-I multiple myeloma and in IgM monoclonal gammopathy

  • Eastern Cooperative Study Group on Monoclonal Gammopathies
Original Article

DOI: 10.1007/BF01697398

Cite this article as:
Eastern Cooperative Study Group on Monoclonal Gammopathies Ann Hematol (1992) 64: 123. doi:10.1007/BF01697398


Interferon (IFN)-a can induce objective responses in advanced-stage multiple myeloma (MM) and can delay disease progression in patients responsive to chemotherapy. We studied the effects of low-dose (3 MU daily) human recombinant IFN-α 2b for 6–12 months in 29 consecutive cases of previously untreated, stablephase, early stage, monoclonal gammopathy (MG) (23 cases of stage I MM and six cases of IgM MG). In 25/29 patients, the disease remained stable throughout the study period. A major objective response was observed in one of five cases of IgA MG. Normal Ig levels increased in all five cases of IgA MG. A significant disease progression occurred in 2/29 cases during the 1-year study period. These data showed that the objective response rate of early-stage MG to low-dose IFN was low and suggested that further investigation should focus on IgA MG.

Key words

Interferon Myeloma Monoclonal gammopathy 

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Eastern Cooperative Study Group on Monoclonal Gammopathies
    • 1
  1. 1.Chair of Hematology, Institute of Experimental and Clinical MorphologyUdine University School of MedicineUdineItaly

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