Annals of Hematology

, Volume 67, Issue 4, pp 169–173

Effect of recombinant human erythropoietin after allogeneic bone marrow transplantation

  • H. Link
  • T. Brune
  • G. Hübner
  • H. Diedrich
  • M. Freund
  • M. Stoll
  • D. Peest
  • W. Ebell
  • C. Bettoni
  • W. Oster
  • U. Nicolay
  • H. Heinrichs
Original Article

Summary

The hematologic effects of recombinant human erythropoietin after allogeneic bone marrow transplantation (BMT) were studied. Nineteen patients received 150 U/kg/day of C127 mouse-cell-derived recombinant human erythropoietin (rHu EPO) as a daily continuous intravenous infusion until hematocrit exceeded 35%. These data were compared with a treatment-matched historical control group of 43 patients. RHu EPO-treated patients recovered erythropoiesis more rapidly and became independent from erythrocyte transfusions after a median of 17 days, which was 7 days earlier than the control patients.

Key words

BMT Recombinant human erythropoietin Regeneration of erythropoiesis Erythrocyte transfusion 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • H. Link
    • 1
  • T. Brune
    • 2
  • G. Hübner
    • 1
  • H. Diedrich
    • 1
  • M. Freund
    • 1
  • M. Stoll
    • 1
  • D. Peest
    • 1
  • W. Ebell
    • 1
  • C. Bettoni
    • 1
  • W. Oster
    • 2
  • U. Nicolay
    • 2
  • H. Heinrichs
    • 2
  1. 1.Interdisciplinary Unit for Bone Marrow TransplantationMedical SchoolHannoverGermany
  2. 2.BehringwerkeMarburgGermany
  3. 3.Department of Hematology and OncologyMedical School HannoverHannoverGermany

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