Hydroxyapatite particle migration

  • P. Frayssinet
  • J. P. Vidalain
  • X. Ranz
  • J. C. Cartillier
  • N. Rouquet
Sotest The use of hydroxyapatite in orthopaedic surgery: a 10-year experience 1986–1999

Summary

HA-coatings have a complex structure due to modification of the crystallographic structure of the HA and the appearance of other calcium phosphate phases during spraying. These modifications are responsible for enhancing of the coating degradation rate by cells and extracellular fluids. Calcium phosphate debris of different sizes and characteristics is released during this degradation and phagocytosed by macrophages or integrated within the newly formed bone. The phagocytosed debris are dissolved in the low pH compartment of the cells and do not trigger osteoclast activation. Some concerns have been raised about the hypothetical particle migration to the surface of the polyethylene cup increasing the release of polymeric debris by a third body wear process. However, the presence of calcium phosphate particles is observed at the surface of polyethylene cups even when implanted with non-coated devices. Thus, the fate of calcium phosphate debris differs to that of metal and polymer due to the characteristics and degradability within the cells of this former.

Key words

Hydroxyapatite 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bloebaum RD, Beeks D, Dorr LD, Savory CG, DuPont AJ, Hofmann AA (1994) Complications with hydroxyapatite particulate separation in total hip arthroplasty. Clin Orthop Rel Res 298: 19–26Google Scholar
  2. 2.
    Frayssinet P, Hardy D, Hanker JS, Giammara BL (1995) Natural history of bone response to hydroxyapatite-coated hip prostheses implanted in humans. Cells Materials 5: 125–138Google Scholar
  3. 3.
    Frayssinet P, Gineste L, Bonel G, Rouquet N (1997) Calcium phosphate particles are found at the polyethylene insert surface whether implanted with HA-coated devices or not. In: Sedel L, Rey C (eds) Bioceramics, Vol. 10. Elsevier, OxfordGoogle Scholar

Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • P. Frayssinet
    • 1
    • 4
  • J. P. Vidalain
    • 2
  • X. Ranz
    • 1
  • J. C. Cartillier
    • 2
  • N. Rouquet
    • 3
  1. 1.DePuy-BiolandToulouseFrance
  2. 2.Clinique d'ArgonnayArgonnayFrance
  3. 3.Clinique MutualisteRue TardieuxLyonFrance
  4. 4.Laboratoire du Tissu Osseux et des Pathologies OstéoarticulairesUniversité Paul SabatierToulouseFrance

Personalised recommendations