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Annals of Hematology

, Volume 64, Issue 6, pp 270–272 | Cite as

Retinoic acid in the treatment of acute promyelocytic leukemia: Inefficacy of the 13-cis isomer and induction of complete remission by the all-trans isomer complicated by thromboembolic events

  • V. Runde
  • C. Aul
  • T. Südhoff
  • A. Heyll
  • W. Schneider
Original Article

Summary

The clinical course of three patients with acute promyelocytic leukemia receiving all-trans retinoic acid (ATRA) as a single agent is reported. The first two patients were in first and second relapse of their leukemia that had occurred despite maintenance treatment with 13-cis retinoic acid after chemotherapy-induced complete remission (CR). A switch to ATRA was followed by achievement of a CR in two patients. The third patient received ATRA as first-line therapy. Two patients experienced thromboembolic complications during the phase of ATRA-induced leukocytosis. One of them died of pulmonary embolism on day 16 of treatment. The two responding patients who did not receive consolidation chemotherapy relapsed after 6 and 9 months, respectively. Increase of the ATRA dose failed to induce a new remission.

Key words

Acute promyelocytic leukemia Retinoic acid Thromboembolism 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • V. Runde
    • 1
  • C. Aul
    • 1
  • T. Südhoff
    • 1
  • A. Heyll
    • 1
  • W. Schneider
    • 1
  1. 1.Department of Internal Medicine, Hematology and Oncology DivisionHeinrich Heine UniversityDüsseldorfGermany

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