Antibiotic resistance inSalmonella enterica serotype typhimurium

  • U. Groß
  • H. Tschäpe
  • I. Bednarek
  • M. Frosch


In order to analyse the development of antibiotic resistance inSalmonella spp., a total of 262Salmonella strains isolated in 1987 (n=148) and in 1996 (n=114) from clinical specimens in Würzburg, Germany, were tested in parallel by the agar diffusion method. In 1987, most of the strains wereSalmonella enterica serotype typhimurium (42.6%), whereas in 1996 most wereSalmonella enterica serotype enteritidis (68.4%). The majority ofSalmonella enterica serotype enteritidis isolates was fully susceptible in 1987 and 1996. In contrast, the percentage of drug-resistant strains ofSalmonella enterica serotype typhimurium increased significantly from 27% in 1987 to 52.4% in 1996. This increase, which might reflect uncontrolled use of antibiotics in the environment, should be of concern to public health authorities.


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  1. 1.
    Levy SB, FitzGerald GB, Macone AB: Changes in intestinal flora of farm personnel after introduction of a tetracycline-supplemented feed on a farm. New England Journal of Medicine (1976) 295:583–588PubMedGoogle Scholar
  2. 2.
    Ling JM, Lo NWS, Ho YM, Kam KM, Ma CH, Wong SC, Cheng AF: Emerging resistance inSalmonella enterica serotype typhi in Hong Kong. International Journal of Antimicrobial Agents (1996) 7:161–166Google Scholar
  3. 3.
    Kariuki S, Gilks C, Corkill J, Kimari J, Benea A, Waiyaki P, Hart CA: Multidrug-resistant non-typhi salmonellae in Kenya. Journal of Antimicrobial Chemotherapy (1996) 38:425–434PubMedGoogle Scholar
  4. 4.
    Rowe B, Ward LR, Threlfall EJ: Multidrug-resistantSalmonella typhi: a worldwide epidemic. Clinical Infectious Diseases (1997) 24, Supplement 1:106–109Google Scholar
  5. 5.
    Sack RB, Rahman M, Yunus M, Khan EH: Antimicrobial resistance in organisms causing diarrheal disease. Clinical Infectious Diseases (1997) 24, Supplement 1:102–105Google Scholar
  6. 6.
    Threlfall EJ, Rowe B, Ferguson JL, Ward LR: Increasing incidence of resistance to gentamicin and related aminoglycosides inSalmonella typhimurium phage type 204c in England. Wales and Scotland. Veterinary Record (1985) 117:355PubMedGoogle Scholar
  7. 7.
    Anonymous: Zur Situation bei ausgewählten meldepflichtigen Infektionskrankheiten im Jahr 1996. Teil 1: Darminfektionen (Gastroenteritiden). Epidemiological Bulletin (1997) 8:49–51Google Scholar
  8. 8.
    Balows A, Hausler WJ, Hermann KL, Isenberg HD, Shadomy HJ (eds): Manual of clinical microbiology. American Society for Microbiology, (1993) Washington, DC. USAGoogle Scholar
  9. 9.
    National Committee for Clinical Laboratory Standards: Performance standards for antimicrobial disc susceptibility tests. 2nd Edition. NCCLS, Villanova, PA, 1979Google Scholar
  10. 10.
    Jensen G, Wandall DA, Gaarslev K, Panavas S, Gutschik E: Antibiotic resistance inShigella andSalmonella in a region of Lithuania. European Journal of Clinical Microbiology & Infectious Diseases (1996) 15:872–876Google Scholar
  11. 11.
    Rowe B, Threlfall JE, Ward LR, Ashley AS: International spread of multiresistant strains ofSalmonella typhimurium phage types 204 and 193 from Britain to Europe. Veterinary Record (1979) 105:468–469PubMedGoogle Scholar
  12. 12.
    Liesegang A, Prager R, Streckel W, Rabsch W, Gericke B, Seltmann G, Helmuth R, Tschäpe H: Wird derSalmonella- enterica-Stumm DT104 des Serovars Typhimurium der neue führende Epidemietyp in Deutschland? Infektions-Forschung (1997) I: 6–10Google Scholar
  13. 13.
    Glynn MK, Bopp C, Dewitt W, Dabney P, Mokhtar M, Angulo F: Emergence of multidrug-resistantSalmonella enterica serotype typhimurium DT104 infections in the United States. New England Journal of Medicine (1998) 338:1333–1338PubMedGoogle Scholar
  14. 14.
    Hof H, Ehrhard I, Tschäpe H: Presence of quinolone resistance in a strain ofSalmonella typhimurium. European Journal of Clinical Microbiology & Infectious Diseases (1991) 10:747–749Google Scholar
  15. 15.
    Helmuth R, Protz D: How to modify conditions limiting resistance in bacteria in animals and other reservoirs. Clinical Infectious Diseases (1997) 24, Supplement 1:136–138Google Scholar

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • U. Groß
    • 1
  • H. Tschäpe
    • 2
  • I. Bednarek
    • 1
  • M. Frosch
    • 1
  1. 1.Institute of Hygiene and MicrobiologyUniversity of WürzburgWürzburgGermany
  2. 2.Robert-Koch-InstituteWernigerodeGermany

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