Chronic meningitis due to herpes simplex virus in an immunocompetent host
- 64 Downloads
Herpes simplex virus (HSV) typically causes mucocutaneous disease, encephalitis, and acute meningitis. There have been no previous reports of chronic meningitis due to this virus. A case of chronic meningitis due to herpes simplex virus type 2 (HSV-2) in a previously healthy 35-year-old woman whose predominant symptoms were headache and meningism without fever is described. Analysis of cerebrospinal fluid (CSF) revealed a lymphocytic pleocytosis, elevated protein, and hypoglycorrhachia. The diagnosis of herpes simplex meningitis was supported by the detection of HSV-2 DMA in CSF by polymerase chain reaction and by intrathecal production of HSV-specific antibody. The patient recovered after treatment with intravenous acyclovir and glucocorticoids.
KeywordsPolymerase Chain Reaction Glucocorticoid Meningitis Cerebrospinal Fluid Herpes Simplex Virus
Unable to display preview. Download preview PDF.
- 1.Tucker T, Ellner JJ: Chronic meningitis. In: Scheid WM, Whitley RJ, Durack DT (ed): Infections of the central nervous system. Raven Press, New York, 1991, p. 703–728.Google Scholar
- 2.Gripshover BM, Ellner JJ: Chronic meningitis. In: Mandell GL, Bennett JE, Dolin R (ed): Principles and practice of infectious diseases. Churchill Livingstone, New York, 1995, p. 865–874.Google Scholar
- 3.Powell KF, Anderson NE, Frith RW, Croxson MC: Non-invasive diagnosis of herpes simplex encephalitis. Lancet 1990, 335: 357–358.Google Scholar
- 8.Boerman RH, Arnoldus EPJ, Bleom BR, Raap AK, Peters ACB: PCR in herpes simplex infections of the central nervous system. Serodiagnosis and Immunotherapy in Infectious Disease 1994, 6: 179–184.Google Scholar
- 9.Bergstrom T, Alstig K: Treatment of primary and recurrent herpes simplex virus type 2 induced meningitis with acyclovir. Scandinavian Journal of Infectious Diseases 1990, 22: 238–240.Google Scholar