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The modes of inhibitory effects of PCBs on oxidative phosphorylation of mitochondria

Summary

The modes of inhibitory effects of 3 PCBs, KC-300,-400 and -500, on oxidative phosphorylation of respiring mitochondria were studied. It was found that the toxicity potency of the PCBs increases with lower chlorine content. The modes of inhibition of the 3 PCBs with regard to antagonism and toxicity, were found to be different according to their composition. KC-300 was only an energy transfer and electron transfer system inhibitor at all concentration levels in contrast with KC-400 and -500, which were energy transfer and electron transfer system inhibitors at low concentrations but had an uncoupling effect at higher concentrations. A slight difference in inhibitory effects between KC-400 and -500 was also observed.

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Sivalingan, P.M., Yoshida, T. & Inada, Y. The modes of inhibitory effects of PCBs on oxidative phosphorylation of mitochondria. Bull. Environ. Contam. Toxicol. 10, 242–247 (1973). https://doi.org/10.1007/BF01684552

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Keywords

  • Toxicity
  • Waste Water
  • Chlorine
  • Water Management
  • Electron Transfer