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The modes of inhibitory effects of PCBs on oxidative phosphorylation of mitochondria


The modes of inhibitory effects of 3 PCBs, KC-300,-400 and -500, on oxidative phosphorylation of respiring mitochondria were studied. It was found that the toxicity potency of the PCBs increases with lower chlorine content. The modes of inhibition of the 3 PCBs with regard to antagonism and toxicity, were found to be different according to their composition. KC-300 was only an energy transfer and electron transfer system inhibitor at all concentration levels in contrast with KC-400 and -500, which were energy transfer and electron transfer system inhibitors at low concentrations but had an uncoupling effect at higher concentrations. A slight difference in inhibitory effects between KC-400 and -500 was also observed.

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  1. 1.

    RONALD S. PARDINI, Bull. Envir. Contam. & Toxicol.6, 539, (1971)

  2. 2.

    FUJIWARA and KUNITACHI,In Lecture Notes of the 32nd Lecture on Gas Chromatography sponsored by Shimadzu: (1972)

  3. 3.

    SCHNEIDER, W.C. and HOGEBOOM, G.H., J. Biol. Chem.183, 123, (1950)

  4. 4.

    ESTABROOK, R.W., Mitochondrial Respiratory Control and the Polarographic Measurement of ADP:O Ratios.In Methods of Enzymology: (Estabrook, R.W. and Pullman, M.E. Ed.),X, pp 41–47 (1967), Academic Press, New York and London.

  5. 5.

    ERNSTER, L., CHUAN-PU LEE and JANDA, S., The Reaction Sequence in Oxidative Phosphorylation.In Biochemistry of Mitochondrial (Slater, E.C., Kaniuga, Z. and Wojtczak. Ed.), pp 29–51 (1966), Academic Press, New York.

  6. 6.

    OZAWA, T., ASAI, J. and UTSUMI, K., Oxidative Phosphorylation and Respiratory Patterns of Mitochondria.In Mitochondria-Its Molecular Organization and Physiological Chemistry: (Ozawa, T., Asai, J. and Utsumi, K. Ed.), pp 190–200 (1971), Nankodo Press, Tokyo.

  7. 7.

    SHIGEYASU KOBAYASI and KUNIO TAGAWA, Proteins, Nucleic Acids and Enzymes,10, 1596, (1965)

  8. 8.

    YONEDA, M., Oxidative Phosphorylation of Mitochondria.In Biological Membrane Experimental Techniques: (Oonishi, T. Ed.), pp 241–248 (1967), Nankodo Press, Tokyo.

  9. 9.

    HOOPINGARNER,In Meetings on PCBs (abstract): (Dec., 1971), Durham, N.C., USA.

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Sivalingan, P.M., Yoshida, T. & Inada, Y. The modes of inhibitory effects of PCBs on oxidative phosphorylation of mitochondria. Bull. Environ. Contam. Toxicol. 10, 242–247 (1973).

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  • Toxicity
  • Waste Water
  • Chlorine
  • Water Management
  • Electron Transfer