Fatigue in women treated with bone marrow transplantation for breast cancer: A comparison with women with no history of cancer
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As more individuals undergo autologous bone marrow transplantation (BMT), there is growing interest in the impact of treatment side effects on quality of life. Fatigue is a potentially disruptive treatment side effect that has not been systematically assessed following BMT. The primary aim of this study was to determine whether the severity of fatigue and its impact on quality of life is significantly greater in women who had undergone BMT for breast cancer than in women of similar age with no history of cancer. Another aim was to identify the medical and psychosocial correlates of fatigue in women who had completed BMT. A group of women treated with autologous BMT for breast cancer (n = 43; mean age = 44; mean time since BMT = 20 months) and a group of women of similar age with no history of cancer (n = 43; mean age = 46) participated in this study. Subjects completed measures of fatigue, anxiety, depression, and sleep habits. Medical data were obtained from computerized patient records. Women who had completed BMT for breast cancer reported significantly more frequent and severe fatigue than women with no cancer history. In addition, fatigue had a significantly greater impact on daily functioning and quality of life in BMT recipients than in women with no cancer history. Fatigue following BMT for breast cancer was related to both medical factors (i.e., time since BMT) and psychosocial factors (i.e., anxiety, depressive symptoms and sleep difficulties). Following BMT for breast cancer, women may experience fatigue that is worse than might “normally” be expected and can interfere with daily functioning and quality of life. Future research should focus on identifying the biological correlates of fatigue, psychological and physiological mechanisms by which fatigue is produced, and interventions to alleviate fatigue.
Key wordsFatigue Bone marrow transplantation
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- 1.Ahles TA, Martin JB (1992) Cancer pain: a multidimensional perspectiv. Noninvasive approaches to pain management in the terminally ill. Hospice J 8:25–48Google Scholar
- 2.Ahles TA, Tope DM, Furstenberg C, et al (1996) Psychological and neuropsychological impact of autologous bone marrow transplantation. J Clin Oncol (in press)Google Scholar
- 3.Aistairs J (1987) Fatigue in the cancer patient: a conceptual approach to a clinical problem. Oncol Nurs Forum 14:25–30Google Scholar
- 9.Buysse DJ, Reynolds CF, Monk TH, et al (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. J Psychiatr Res 28:193–213Google Scholar
- 10.Cella DF, Tross S, Orav EJ, et al (1989) Mood states of patients after the diagnosis of cancer. J Psychosoc Oncol 7:45–54Google Scholar
- 12.Fields KK, Elfenbein GJ, Perkins JB, et al (1994) High dose versus standard dose chemotherapy for the treatment of breast cancer: a review of current concepts. In: Sackstein R, Janssen W, Elfenbein G (eds) Bone marrow transplantation: foundations for the 21st century. The New York Academy of Sciences, New York, pp 288–304Google Scholar
- 14.Fields K, Perkins J, Elfenbein G, et al (1995) A phase I dose escalation trial of high dose TAXOL, NOVAN-TRONE, and thioTEPA (TNT) followed by autologous stem cell rescue (ASCR): toxicity. Proc ASCO 14:322Google Scholar
- 19.McNair DM, Lorr M, Droppleman LF (1981) The manual for the profile of mood states. Educational and Industrial Testing Service, San DiegoGoogle Scholar
- 20.Nail LM, Winningham ML (1993) Fatigue. In: Groenwald S, Goodman M, Frogge MH, Yarbo CH (eds) Cancer nursing: principles and practice, 3rd edn. Jones and Bartlett, Boston, pp 608–619Google Scholar
- 21.Radloff LS (1977) The CES-D Scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1:385–401Google Scholar
- 22.Spielberger CD, Gorsuch RL, Lushene RD (1970) STAI: Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press, Palo AltoGoogle Scholar